Objective To investigate the clinical values of combined detection of serum AFP,AFU and GP73 levels in the early diagnosis of primary hepatic cancer.Methods The serum AFP.AFU and GP73 levels in 56 patients with primary hepatic cancer,85 patients with hepatic benign disease and 60 healthy persons were measured by radio immunologic methods,speed method and enzyme linked immunosorbent assay ( ELISA).Results The levels of serum AFP,AFU and GP73 0f primary hepatic cancer patients were significantly higher than those of hepatic benign disease patients and healthy controls,and there were significant differences (P ＜ 0.05),the positive rates of serum AFP,AFU and GP73 were 66.1％,76.8％,82.1％ in patients with primary hepatic cancer.With combined detection of serum AFP,AFU and GP73,the positive rate of primary hepatic cancer could be enhanced to 94.6％.Conclusions The combined detection of serum AFP,AFU and GP73 levels could increase.the diagnostic sensitivity of primary hepatic cancer,especially primary hepatic cancer with negative AFP,it is valuable for the early diagnosis of primary hepatic cancer.