Objective To study the clinical and pathological features of calcifying epithelioma,and improve the defferential diagnosis level of the disease.Methods The clinical and pathological data of 36 cases of calcifying epithelioma confimed with pathology in the pathology department after surgical resection from January 2005 to December 2011 were retrospectively analyzed.Results The diseased region were upper arm,head and neck:88.89％ (32/36) calcification of epithelial tumors were younger than 29 years,77.78％ (28/36)were misdiagnosed as others diseases,and without recurrence after surgical resection.The basophilic and shadow cells were arranged mainly in tissue.Conclusions Calcifying epithelioma occures mainly in upper arm,head and neck of young people.It has higher rate of clinical misdiagnosis,without recurrence after surgical resection,and a variety of clinical manifestations,which may contribute to its diagnosis.