Objective To investigate the occurrence rule,clinical characteristic and effective therapy of hand-foot-mouth disease(HFMD).Methods The clinical data of 146 hospitalized children with severe HFMD were analyzed,and the clinical characteristic and occurrence rule of severe HFMD was summarized.Results All of the 146 children with severe HFMD had onset of rash and fever and their duration of fever were more than 36 hours.Duration of fever in 146 cases were less than 96 hours and 4 cases were less than 120 hours.The range of all body temperture were from 37.8 ℃ to 40.5 ℃.The early clinical manifestaions were startle,limbs shaking,headache and constipation.All of the children received therapy of mannitol,intravenous gamma globulin and glucocorticoid.Conclusions The fever is an important risk factor for severe HFMD,and the occurrence,development and prognosis of severe hand-foot-mouth disese have a certain regularity.