Changes of coagulation index and pulmonary artery pressure in chronic obstuctive pulmonary disease combined with pulmonary embolism
ZHANG Jia, MA Dong-bo, JIA Yao-li, KANG Bei-bei, DENG Shu-ping, JIN Jian-jun, WANG Jing
Published 2013-05-25
Cite as Chin J Pract Med, 2013,40(10): 37-38. DOI: 10.3760/cma.j.issn.1674-4756.2013.10.016
Abstract
Objective To Observe the changes of coagulation index and systolic pulmonary artery pressure (SPAP) in patients with chronic obstructive pulmonary disease(COPD) combined with pulmonary embolism(PE).Methods Two hundred patients who were hospitalized in the first affiliated hospital of Zhengzhou university between June 2010 to June 2012 were selected,there were 164 patients with simple COPD and 36 patients with COPD combined with PE.Fifty healthy controls were selected as the control group.Prothrombin time (PT),activated partial thromboplastintime (APTT),thrombittime (TT),fibrinogen (Fbg) were determined with immunoturbidimetry,D-dimer (D-D) were determined with ELISA,and the systolic lung artery pressure were determined by colour doppler ultrasound.Results Compared with the simple COPD patients,the Fbg,D-D,SPAP of patients with COPD combined with PE were higher,APTT was shorter.Conclusions Patients with COPD combined with PE had hypercoagulable state and hyperfibrinolysis,and the systolic pulmonary artery pressure was higher than that of simple COPD patients.
Key words:
Chronic obstuctive pulmonary disease; Pulmonary embolism; Coagulation index; Systolic pulmonary artery pressure
Contributor Information
ZHANG Jia
Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Zhengzhou University, ZhengZhou 450052, China
MA Dong-bo
Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Zhengzhou University, ZhengZhou 450052, China
JIA Yao-li
Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Zhengzhou University, ZhengZhou 450052, China
KANG Bei-bei
Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Zhengzhou University, ZhengZhou 450052, China
DENG Shu-ping
Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Zhengzhou University, ZhengZhou 450052, China
JIN Jian-jun
Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Zhengzhou University, ZhengZhou 450052, China
WANG Jing
Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Zhengzhou University, ZhengZhou 450052, China
