Objective To investigate the effects of rosuvastatin and fluvastatin on serum lipids,bone mineral density(BMD) in postmenopausal coronary heart disease patients with osteoporosis.Methods One hundred and seventeen cases of postmenopausal coronary heart disease with osteoporosis were randomly divided into group A(n =60) and group B(n =57).Rosuvastatin 10 mg per night were given in group A,fluvastatin 80 mg per night was given in group B.The follow-up lasted for 40 weeks.Serum lipids and bone mineral density were measured before treatment and after 40 weeks.Results Compared with pretherapy,serum total cholesterol,triglycerides,and low density lipoprotein cholesterol were lower,high density lipoprotein cholesterol was higher after treatment in both groups(P ＜ 0.05).Serum lipids in group A were more significant than that in group B (P ＜ 0.05).The parameter value of bone density at lumar vertebrae 2-4 and proximal femur(Neck and Troch) were all significantly increased in two groups (P ＜ 0.05).Conclusions Both rosuvastatin and fluvastatin have satisfactory regulations on hyperlipoidemia in postmenopausal CHD with osteoporosis,and rosuvastatin was superior to fluvastatin.Both rosuvastatin and fluvastatin may increased bone density of postmenopausal CHD with osteoporosis.