Objective To investigate the relationship among anticardiolipin antibodies (ACA),C-reactive protein (CRP) and deep vein thrombosis after skeletal trauma.Methods One hundred and ninety-six patients with skeletal trauma were chosen for the study,23 cases of which were definitely diagnosed by color Doppler.One hundred and sixteen healthy subjects were chose as control group.The level of anticardiolipin antibodies was assayed by enzyme linked immunoabsorbent assay (ELISA),and CRP was determined by rate nephelometry.Results CRP levels in patients with skeletal trauma were significantly high,but lower than in patients with deep venous thrombosis ; Positive rate of ACA in patients with deep vein thrombosis was significantly higher,five cases of ACA-positive skeletal trauma patients suffered from DVT; Positive rate of CRP in lower extremity fractures,multiple fractures group or pelvic fracture group was significantly higher than that in the upper limb fracture group (P ＜ 0.05).Conclusions ACA and CRP may be associated with skeletal trauma; ACA is an independent risk factor for DVT.