Objective To investigate the changes of clinical features and analysis of prognosis for inpatients with prostate cancer in Zhengzhou city.Methods A total of 789 patients with complete follow-up data of histological-proven prostate cancer diagnosed during period from 2005 to 2010 at 6 department of urology in Zhengzhou city were retrospectively collected.The average age of patients in this cohort was 71.5 years old(range 57-85 years old).According to the time of diagnosis,the patients were divided into two groups:early group (2005-2007) and contemporary group (2008-2010).The ages,smoke,drink,prostate volume,PSA,Gleason scores,tumor stages,bone metastasis,LUTS symptom,treatment options and medical payment were compared to determine whether the discrepancies were significant.The survival rate of patients was analyzed using Kaplan-Meier method.Prognostic factors were analyzed using the log-rank test and Cox proportional hazards model.Results The differences of ages,PSA levels,tumor stages,bone metastasis and treatment options between the two groups were significant (all P ＜0.05).The overall 3-year survival rate was 52.4％ and 75.6％ for early and contemporary groups respectively,and there was significant difference (P ＜ 0.05).Cox regression suggested that ages,Gleason scores,bone metastasis and treatment options were independent factors affecting the prognosis in early group,and Gleason scores,tumor stages,bone metastasis and treatment options were independent factors affecting the prognosis in contemporary group.Conclusions This study provides up-to-date evidence that the management of prostate cancer has made tremendous progress in Zhengzhou city,the 3-year overall survival rate of prostate cancer has significantly increased through promoting the levels of diagnosis and treatment.It is highly important of screening prostate cancer for old men and improving medical insurance policy to detect patients with earlier stage tumor.