Objective To investigate the value of the fetal heart monitoring,umbilical artery (UA),middle cerebral artery (MCA) and ductusvenosus shunting ratio as well as combing the four markers 9n predicting fetal distress in pregnancy.Methods One hundred and five cases of late pregnant women who were suspected with fetal distress were selected.Fetal monitoring was examined in 105 pregnant women.Resistance index(RI),pulsatility index(PI) and the peak systolic velocity(S) and end diastolic velocity(D) ratio(S/D) of fetal middle cerebral artery and umbilical artery were detected.The blood flow volume of fetal ductus venosus and umbilical vein were measured,the blood flow volume ratio of ductus venosus was calculated.The results were analyzed.Results The sensitivity of NST,MCA,UA and ductus venosus shunting ratio in predicting fetal hypoxia alone was 65.32％,68.23％,67.26％,61.20％.The sensitivity of combing NST + MCA + UA + Ductus venosus shunting ratio was higer(P ＜0.01).Conclusions The method of combining NST + MCA + UA + Ductus Venosus Shunting Ratio has higher sensitivity and specificity in predicting fetal distress.