Original Article
Effect of alprostadil injection on liver function of patients with liver cirrhosis
Xuejuan Fan, Zhen Wang, Lan Zhang, Ning Cui
Published 2016-06-25
Cite as Chin J Pract Med, 2016, 43(12): 36-38. DOI: 10.3760/cma.j.issn.1674-4756.2016.12.015
Abstract
ObjectiveTo observe the efficacy of alphrostadil injection on patients with decompensated cirrhosis.
MethodsA toatal of 112 patients with decompensated cirrhosis were selected and randomly divided into treatment group and control group, with 56 cases in each group. The patients in control group were treated with conventional liver protection and support treatment, while the patients in treatment group were given alphrostadil injection on the basis of conventional treatment. The changes of liver function index including alanine aminotransferase(ALT), total bilirubin(TBIL), albumin(ALB), prothrombin cativity(PTA), ascites and complications were compared.
ResultsThe levels of ALT, TBiL were significant decreased and the levels of ALB, PTA were increased after treatment in both groups(P<0.05). The changes of ALT, TBiL were more significant in treatment group compared with the control group(P<0.05). The regression of ascites in treatment group were more significant than those in the control group(P<0.05). There was no significant difference between the two groups in the change of ALB or PTA(P>0.05).
ConclusionsAlphrostadil can improve the liver function of patients with liver cirrhosis, it had considerable effects on decompensated cirrhosis.
Key words:
Alphrostadil; Liver cirrhosis; Liver function
Contributor Information
Xuejuan Fan
Department of Infectious Disease, the 154th Central Hospital of Chinese People's Liberation Army, Xinyang 464000, China
Zhen Wang
Lan Zhang
Ning Cui