Efficacy of xiyanping and vidarabine on children with viral encephalitis and its influence on T cell subsets
Yang Xiaoli, Yin Ya’nan, Hu Wenmiao, Zhu Hongwen, Zhang Lifei, Tong Li
Published 2017-06-25
Cite as Chin J Pract Med, 2017,44(12): 88-90. DOI: 10.3760/cma.j.issn.1674-4756.2017.12.028
Abstract
ObjectiveTo investigate the efficacy of xiyanping combined with vidarabine on children with viral encephalitis and its influence on T cell subsets.
MethodsA total of 98 children with viral encephalitis were selected from April 2015 to March 2016, and were divided into the two groups according to treatment options, with 49 cases in each group. The control group was treated by adenosine, the study group was given adenosine and Xiyanping. Two groups were treated with continuous 7 d. The effect and T cell subsets (CD3+ 、CD4+ 、CD8+ ) levels were compared between the two groups.
ResultsThe total effective rate of the study group was 93.88%(46/49), which of the of the control group was 79.60%(39/49), the difference was significant (P<0.05). The disappearance time, the disappearance time of headache, the disappearance time of fever and the recovery of consciousness of the study group were less than those of the control group, and the differences were significant (P<0.05). After the treatment, CD3+ (62.4±7.2)/μl, CD4+ (51.3±8.1)/μl, CD8+ (32.3±7.3)/μl of the study group were better than those of the control group, the differences were significant (P<0.05). The incidence rate in the study group was 14.28%(7/49), which of the of the control group was 32.65%(16/49), the difference was significant (P<0.05). The incidence rate of adverse reaction in the study group was 6.12%(3/49), which of the of the control group was 4.08%(2/49), the difference was not significant (P>0.05).
ConclusionsThe effect of Xiyanping combined with vidarabine on children virus encephalitis is exact, and it can effectively relieve the clinical symptoms, and can improve the level of T cell subsets reduce sequelae, and it is safe.
Key words:
Children viral encephalitis; T cell subsets; Xiyanping; Adenosine
Contributor Information
Yang Xiaoli
Department of Paediatrics, the Third People’s Hospital of Zhengzhou, Zhengzhou 450000, China
Yin Ya’nan
Department of Neurology, the Second People’s Hospital of Zhengzhou, Zhengzhou 450000, China
Hu Wenmiao
Department of Paediatrics, the Third People’s Hospital of Zhengzhou, Zhengzhou 450000, China
Zhu Hongwen
Department of Paediatrics, the Third People’s Hospital of Zhengzhou, Zhengzhou 450000, China
Zhang Lifei
Department of Paediatrics, the Third People’s Hospital of Zhengzhou, Zhengzhou 450000, China
Tong Li
Department of Paediatrics, the Third People’s Hospital of Zhengzhou, Zhengzhou 450000, China
