To investigate the clinical characteristics of serum myocardial enzymes spectrum and the correlation between them and diabetic microangiopathy.

The clinical data of all the patients with type 1 or type 2 diabetes mellitus during the first half year of 2015 were retrospectively analyzed. After ruled out the cases without detective indexes, 405 cases were selected. Marked group A and group B with patients combined cardiac enzyme rising and uncombined cardiac enzyme rising.To record the glycosylated hemoglobin, fasting blood glucose, fasting C peptide, lipids(cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol), myocardial enzymes spectrum[aspartate aminotransfrrase(AST), lactate dehydrogenase (LDH) and it’s isoenzyme (LDH-1), and creatine kinase (CK) and it’s isoenzyme (CK-MB), α-hydroxybutyrate dehydrogenase (α-HBDH), ischemia modified albumin (IMA)], liver function, renal function, whether suffering from diabetic microangiopathy or other complications of the two groups.

There were 116 patients with myocardial enzyme elevation, accounting for 28.6% of the total patients; Disease duration, age and the levels of AST, uric acid, cystatin C, retinol binding protein, creatinine clearance rate, the proportion of diabetic nephropathy (66.4% vs 27.3%) and diabetic retinopathy (65.5% vs 51.2%) had significant differences between the two groups (P<0.05).

There is correlation of the elevation of myocardial enzymes spectrum with diabetic microvascular disease. The LDH, LDH-1 and α-HBDH have greater reference value. By detecting myocardial enzymes, doctor can uncover the clue of diabetic microangiopathy including diabetic cardiomyopathy.

Myocardial enzyme spectrum; Diabetic microvascular disease; Diabetic cardiomyopathy; Correlation