Effects of acarbose on blood glucose in patients with severe acute pancreatitis
Zhang Jin, Liang Gang, Guo Yuntong
Published 2018-06-10
Cite as Chin J Pract Med, 2018,45(11): 111-113. DOI: 10.3760/cma.j.issn.1674-4756.2018.11.038
Abstract
ObjectiveTo investigate the effects of acarbose injection by enteral nutrition tube on blood glucose levels in patients with severe acute pancreatitis.
MethodsSixty patients with severe acute pancreatitis were selected and randomly divided into observation group and control group, with 30 cases in each group. Patients in observation group were treated with nasojejunal tube injection of acarbose. Patients in control group were given normal insulin by infusion pump. The body mass index (BMI), C-reactive protein, blood calcium value, Apache-Ⅱ score, average blood sugar, daily mean of insulin, days of insulin use, hospital stay, maximum daily blood glucose fluctuation (LAGE) and standard deviation of daily blood glucose (SDBG) were statistically analyzed and compared between the two groups.
ResultsThere was no significant difference in BMI, C-reactive protein, blood calcium, the acute physiological and chronic health score (Apache-Ⅱ score), average blood sugar and the days of using insulin between the two groups (P>0.05). The hospital stay, insulin daily average, LAGE and SDBG in observation group were all smaller than those in control group, the difference was statistically significant (P<0.05).
ConclusionsIn patients with severe acute pancreatitis, the method of injecting dissolved acarbose into the jejunum nutrition tube has achieved the aim of clinically stable blood glucose and control of blood glucose fluctuations.
Key words:
Acarbose; Severe acute pancreatitis; Blood glucose levels; Blood glucose
Contributor Information
Zhang Jin
Department of General Surgery, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
Liang Gang
Department of Pathology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
Guo Yuntong
Department of General Surgery, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
