Original Article
Effects of different blastocyst culture strategies on patients with repeated implantation failure
Dalin Wang, Hong She, Fang Chen, Fang Lyu, Yanqiu Hu
Published 2019-07-10
Cite as Chin J Pract Med, 2019, 46(13): 11-14. DOI: 10.3760/cma.j.issn.1674-4756.2019.13.003
Abstract
ObjectiveTo compare the effects of different blastocyst culture strategies on patients with repeated implantation failure (RIF), and to provide better measures for RIF patients to get clinical pregnancy opportunities.
MethodsRetrospective analysis was performed on the results of the fresh blastocyst culture and blastocyst culture after frozen-thawed cleavage stage embryo in 249 RIF patients from August 2011 to June 2016 in Reproductive Medical Centre of Northern Jiangsu People’s Hospital. Patients were divided into two group according to blastocyst culture strategies, fresh blastcyst culture group (166 cycles) and frozen-thawed cleavage stage embryo culture group (93 cycles).
ResultsThere was no significant difference in blastocysts formation rate, transplantable blastocysts formation rate or high quality blastocysts formation rate between fresh blastocyst culture group and frozen-thawed cleavage stage embryo culture group (P>0.05). Clinical pregnancy rate and embryo implantation rate of frozen-thawed cleavage stage embryo culture group were higher than those of fresh blastocyst culture (P>0.05), but there was no significant difference in clinical pregnancy rate between the two groups (χ2=1.617, P>0.05); three was significant difference in embryo implantion rate between the two groups (χ2=9.525, P<0.01). And no significant difference was noted in abortion rate, ectopic pregnancy rate and persistent pregnancy rate between the two groups (P>0.05).
ConclusionsFresh blastocyst culture has similar efficacy to frozen-thawed cleavage stage embryo strategy. They can culture embryo of same quality, and has similar pregnancy outcome after transplantation.
Key words:
Repeated implantation failure; Blastocyst culture; Blastocyst transplantation
Contributor Information
Dalin Wang
Department of Obstetrics and Gynecology, Clinical Medical School of Yangzhou University, Yangzhou, 225000, China
Hong She
Reproductive Medicine Center, Northern Jiangsu People’s Hospital, Yangzhou 225001, China
Fang Chen
Reproductive Medicine Center, Northern Jiangsu People’s Hospital, Yangzhou 225001, China
Fang Lyu
Reproductive Medicine Center, Northern Jiangsu People’s Hospital, Yangzhou 225001, China
Yanqiu Hu
Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
