To investigate the correlation between the drug resistance of Escherichia coli and the use of antibiotics, and to provide reliable data for clinical rational drug use.

The database of antibiotics used by hospitalized patients in Binzhou Central Hospital from 2013 to 2018 was searched. The doses and doses of inpatients (DDDS) were retrospectively analyzed. The relevant data were statistically analyzed and ranked, and the drug resistance rate and production of Escherichia coli were analyzed. The detection rate of extended-spectrum β-lactamase strains was analyzed by Pearson correlation coefficient.

Escherichia coli has the highest resistance to ceftazidime, cefuroxime and ciprofloxacin, and both exceeded 60% in 2017. The detection rate of extended-spectrum β-lactamase strains in Escherichia coli was positively correlated with the dosage of cefepime, fluoroquinolone and carbapenem antibiotics (r=0.9643, 1, 0.888, P<0.05). There was no correlation between the amount of aminoglycosides and β-lactams (P>0.05). The resistance rate of Escherichia coli to ciprofloxacin was positively correlated with the use of fluoroquinolones (r=0.9325, P<0.05), and the resistance rate to cefepime was positively correlated with the use of cefepime (r=0.8635, P<0.05).

Third-generation cephalosporins and fluoroquinolones are not suitable for the treatment of Escherichia coli infections. Both carbapenems and cefepime can be used for the treatment of Escherichia coli infection, but the indications of the drugs should be strictly controlled, and the dosage should be deliberated, and the carbapenems should be applied to Escherichia coli. Severe infection, and β lactamase inhibitors and aminoglycosides are preferred drugs for the treatment of Escherichia coli infection.

Escherichia coli; β-lactamase; Carbapenems