Drug Application
Comparison of analgesic effects of nalbuphine and dizocine on parturients after cesarean section
Guan Xuemei
Published 2019-09-25
Cite as Chin J Pract Med, 2019,46(18): 116-119. DOI: 10.3760/cma.j.issn.1674-4756.2019.18.037
Abstract
ObjectiveTo compare the safety and efficacy of patient controlled intravenous analgesia with nalbuphine and dizocine in parturients after cesarean section.
MethodsA total of 126 women undergoing cesarean section in Jiaozhou People’s Hospital from August 2016 to May 2018 were enrolled. The patients were randomly assigned to the dizocine group (observation group, n=63) and nalbuphine group (control group, n=63) according to the random number table method. The uterine contraction pain visual analogue scale (VAS) score, dynamic pain VAS score and rest pain VAS score were compared at 4 h, 8 h, 12 h, 24 h and 48 h after operation between the two groups. At the same time, the sedation degree of the two groups was evaluated by Ramsay sedation score. The lactation initiation time and serum prolactin (PRL) were compared between the two groups 30 min before surgery, 24 h and 48 h after surgery.
ResultsPostoperative rest VAS score , dynamic pass VAS score, uterine contraction pain VAS score and Ramsay score were significantly decreased with time. At 4 h, 8 h and 12 h after operation, the uterine contraction pain VAS score, dynamic pain VAS score and rest pain VAS score in the observation group were significantly lower than those in the control group (P all <0.05). There was no significant change in the postoperative Ramsay score over time between the two groups(P>0.05). There was no significant difference in the Ramsay score between the observation group and the control group at 4 h, 8 h, 12 h, 24 h and 48 h after operation (P all >0.05). The incidence of adverse reactions was 15.9% (10/63) in the observation group, and 20.6% (13/63) in the control group, and the difference was not significant (χ2=0.479, P=0.489).
ConclusionsBoth nalbuphine and dextrozine have great analgesic effects on postpartum cesarean section. The early analgesic effect of dextrozine is better than that of nalbuphine. The long-term analgesic effect of the two drugs is similar. The safety of the two drugs and their effects on lactation initiation time and serum PRL parameters are similar.
Key words:
Dizocine; Nalbuphine; Cesarean section; Postoperative analgesia
Contributor Information
Guan Xuemei
Department of Pharmacy, Jiaozhou People’s Hospital, Jiaozhou 266300, China
