Original Article
Early efficacy of deep brain stimulation on subthalamic nucleus in the treatment of dysarthria in patients with Parkinson’s disease
Zhang Fengtian, Zhang Yuanyuan
Published 2019-11-10
Cite as Chin J Pract Med, 2019,46(21): 73-75. DOI: 10.3760/cma.j.issn.1674-4756.2019.21.023
Abstract
ObjectiveTo observe the early efficacy of deep brain stimulation (DBS) on subthalamic nucleus (STN) in the treatment of patients with Parkinson’s disease (PD).
MethodsSeventy-six patients with PD treated in Shouguang People’s Hospital from November 2016 to November 2018 were selected as research objects. All the patients were treated with dopaminergic drugs, but didn't have satisfactory efficacy, or could not tolerate adverse drug reactions, or suffered from uncontrollable tremor. All patients were treated by STN-DBS, and the efficacy and incidence of adverse reactions were observed.
ResultsAfter treatment, the non-motor symptom scale and unified Parkinson’s disease rating scale scores decreased significantly (P<0.05); however, mini-mental state examination score and speech fluency score did not change significantly 6 months after operation (P>0.05). There was 1 case transient headache, 3 cases asymptomatic intracranial effusion, 1 case blepharoma and 1 case transient blurry consciousness. All the adverse reactions were slightly unaffected.
ConclusionsSTN-DBS can effectively improve Parkinson’s and non-motor symptoms of patients with PD, without causing cognitive impairment and dysarthria.And it has great early effects.
Key words:
Parkinson’s disease; Deep brain stimulation; Subthalamic nucleus
Contributor Information
Zhang Fengtian
Department of Neurology, Shouguang People’s Hospital, Shouguang 262700, China
Zhang Yuanyuan
Department of Neurology, Shouguang People’s Hospital, Shouguang 262700, China