Drug Application
Efficacy of atorvastatin combined with metformin hydrochloride in the treatment of typeⅡdiabetes mellitus with hypothyroidism
Bai Huiqin, Wang Yanhong, Wei Lihong
Published 2019-12-25
Cite as Chin J Pract Med, 2019,46(24): 93-97. DOI: 10.3760/cma.j.issn.1674-4756.2019.24.028
Abstract
ObjectiveTo observe the efficacy of atorvastatin combined with metformin hydrochloride in the treatment of type Ⅱ diabetes mellitus with hypothyroidism.
MethodsA total of 94 patients with typeⅡdiabetes mellitus complicated with hypothyroidism in General Hospital of Yangquan Coal Group from February 2017 to February 2019 were enrolled. The patients were divided into observation group and control group by random number table method, with 47 cases in each group. The two groups were given atorvastatin and combined with levothyroxine sodium adjuvant therapy, and observation group was additionally given metformin hydrochloride on this basis. The clinical efficacy after 16 weeks of treatment, and blood glucose indexes, including fasting plasma glucose (FPG), postprandial 2 h blood glucose (2hPG), glycosylated hemoglobin (HbA1c), thyroid function-related indicators [serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4)] and oxidative stress indicators, such as reactive oxygen species (ROS), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxide (GSH-PX), before treatment and after 16 weeks of treatment were compared between the two groups.
ResultsAfter 16 weeks of treatment, the total effective rate of treatment in observation group was higher than that in control group (P<0.05). The FPG, 2hPG and HbA1c in the two groups were lower than those before treatment, and the indexes in observation group were lower than those in control group ( P<0.05). The TSH in the two groups was lower than that before treatment while the FT3 and FT4 were higher than those before treatment, and there were statistically significant differences in the TSH and FT4 between the two groups ( P<0.05). The levels of ROS and MDA in the two groups were lower than those before treatment while the levels of SOD and GSH-PX were higher than those before treatment, and there were statistically significant differences in the ROS, MDA, SOD and GSH-PX between the two groups ( P<0.05).
ConclusionsAtorvastatin combined with metformin hydrochloride has exact efficacy in the treatment of type Ⅱ diabetes mellitus with hypothyroidism. It can improve the thyroid function of patients based on effective control of blood glucose.
Key words:
Atorvastatin; Metformin hydrochloride; Type Ⅱ diabetes mellitus; Hypothyroidism
Contributor Information
Bai Huiqin
Department of Endocrinology, General Hospital of Yangquan Coal Group, Yangquan 045000, China
Wang Yanhong
Department of Endocrinology, General Hospital of Yangquan Coal Group, Yangquan 045000, China
Wei Lihong
Department of Endocrinology, General Hospital of Yangquan Coal Group, Yangquan 045000, China
