To investigate the effects of dinoprostone suppository combined with cephalosporin on patients with premature rupture of membranes.

Seventy-two patients with full-term pregnancy and premature rupture of membranes admitted to Luoyang Central Hospital Affiliated to Zhengzhou University from June 2017 to January 2018 were divided into observation group (37 cases) and control group (35 cases) according to their treatment methods. All patients received sporofurin. Meanwhile, the control group was treated with oxytocin, and the observation group were given dinoprostone suppository. The clinical efficacy, delivery outcome, neonatal status, inflammatory factors at admission and after delivery of the two groups were observed.

The total effective rate of the observation group was 91.9% (34/37), significantly higher than the 74.3% (26/35) of the control group (P<0.05). The observation group had more patients with vaginal delivery than the control group (P<0.05). However, the labor time and total stages of labor of the observation group were shorter than those of the control group, and the intrauterine infection rate of the observation group was lower than that of the control group (P<0.05). There were no significant differences in body weight, Apgar score, fetal distress rate or neonatal asphyxia rate between the two groups (P>0.05). The levels of C-reactive protein and interleukin-6 in the observation group were lower than those in the control group (P<0.05).

Dinoprostone suppository combined with cephalosporin is effective in the treatment of premature rupture of membranes, which is conductive to vaginal delivery and reducing the infection risk.

Premature rupture of membranes; Dinoprostone suppository; Cephalosporin; Delivery mode; Maternal and infant outcomes; Inflammatory factors