To investigate the correlation between glomerular filtration rate (estimated glomerular filtration rate, eGFR) and serum total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin(IBIL) in patients with type 2 diabetes mellitus.

According to eGFR level, 523 cases of type 2 diabetic inpatients from October 2011 to September 2012 in Department of Diabetic Nephropathy, Metabolic Diseases Hospital, Tianjin Medical University were divided into four groups: glomerular hyperfiltration group (n=133), normal renal function group (n=194), mild renal dysfunction group (n=125), moderate and severe renal dysfunction group (n=171). The differences of TBIL, DBIL and IBIL levels among the four groups were compared. The related factors analysis of eGFR was perfor, med. Variance analysis was used to analysize mulitiple groups of data.

The bilirubin levels of glomerular hyperfiltration group was significantly lower than normal renal function group (P<0.05). TBIL level was (10.9±4.0) vs (12.5±4.5) μmol/L, DBIL level was (3.8±1.6) vs (4.4±1.7) μmol/L, IBIL level was (7.1±2.8) vs (8.0±3.1) μmol/L. The levels of TBIL, DBIL and IBIL in moderate and severe renal dysfunction group significantly reduced than those of other three groups (F=15.296, 15.024, 11.609, all P<0.05). In the patients with eGFR<130 ml/min, correlation analysis results indicate: eGFR was negatively correlated with age, the course of diabetes, total cholesterol, low-density lipoprotein cholesterol (r=-0.307, -0.203, -0.149, -0.111, all P<0.05), and was positively correlated with TBIL, DBIL and IBIL (r=0.291, 0.275, 0.254, all P<0.05).

Serum bilirubin levels are associated with glomerular filtration rate in patients with type 2 diabetes.

Diabetes mellitus, type 2; Glomerular filtration rate; Bilirubin