Original Article
Association between C-reactive protein and the risk of diabetes
Xianfeng Zhou, Xiaonan Ruan, Siyu Yu, Hua Qiu, Cheng Ni, Xinyi Rui, Yi Zhou, Kang Wu, Xiaonan Wang, Hong Liu, Heli Zhang, Yuping Yao, Xiaolin Liu, Juzhong Ke, Lipeng Hao, Genming Zhao
Published 2017-02-27
Cite as Chin J Diabetes Mellitus, 2017, 09(2): 106-111. DOI: 10.3760/cma.j.issn.1674-5809.2017.02.006
Abstract
ObjectiveTo explore the association between C-reactive protein(CRP) level at baseline and the risk of diabetes mellitus(DM) during follow-up in a community cohort.
MethodsSubjects were the residents (35-74 years old) derived from a community-based diabetes prospective cohort study in Pudong New Area in Shanghai, which began in 2009 and followed up in 2012. Baseline non-diabetic population was divided into four groups according to the level of baseline CRP (CRP<1.00 mg/L, 1.00-1.99 mg/L, 2.00-2.99 mg/L or ≥3.00 mg/L). Analysis of variance, Kruskal Wallis H nonparametric test and Chi-square test were used to compare the baseline characteristics, and COX regression model was used to analyze the association between baseline CRP level and DM risk during follow-up.
ResultsThe mean follow-up time was (2.7±0.5) years. For those with CRP<1.00, 1.00-1.99, 2.00-2.99 and ≥3.00 mg/L, the incidence rate of DM was 14.68/1 000, 21.30/1 000, 28.92/1 000 or 46.38/1 000 person-years, respectively; the incidence rate of DM increased with baseline CRP levels (χlinear2=13.63, P<0.001). After adjusting for family history of diabetes, history of hypertension, age, body mass index, triglycerides, and the baseline blood glucose status, the risk of DM in group with CRP level ≥3.00 mg/L was 3.26 times (95% CI: 1.39-7.64) that of group with CRP level<1.00 mg/L. The areas under the receiver operating characteristic curves of baseline CRP level in predicting the incidence of DM was 0.604 (95% CI:0.522-0.686).
ConclusionsBaseline CRP level is an independent risk factor of diabetes; however, the predict power of CRP is poor. Therefore, combiding CRP with other factors may be a good choice to predict diabetes.
Key words:
Diabetes mellitus; C-reactive protein; Prospective cohort study
Contributor Information
Xianfeng Zhou
Center for Disease Prevention and Control, Pudong New Area, Pudong Preventive Medicine Research Institute of Fudan University, Public Health School, Shanghai 200136, China
Xiaonan Ruan
Siyu Yu
Hua Qiu
Cheng Ni
Xinyi Rui
Yi Zhou
Kang Wu
Xiaonan Wang
Hong Liu
Heli Zhang
Yuping Yao
Xiaolin Liu
Juzhong Ke
Lipeng Hao
Genming Zhao