Original Article
Application of flash glucose monitoring system in children with type 1 diabetes mellitus
Jinlei Bai, Yujin Ma, Liping Li, Liujun Fu, Jie Liu, Keyan Hu, Haiyan Wei, Junhong Wang, Xiangyang Guo, Xiuqin Geng, Min Chen, Dezeng Tian, Yafei Shen, Junhang Tian, Haixia Wu, Yahui Mu, Wenbo Jin, Juzhen Zhao, Lianwei Wang, Zhigang Zhao, Hongyun Wang, Hongwei Jiang
Published 2018-10-27
Cite as Chin J Diabetes Mellitus, 2018, 10(10): 658-662. DOI: 10.3760/cma.j.issn.1674-5809.2018.10.006
Abstract
ObjectiveTo investigate the status of blood glucose control in children with type 1 diabetes mellitus (T1DM) in Henan Province, and the safety of flash glucose monitoring system (FGMS) in children with T1DM.
MethodsBetween August 2017 and February 2018, 116 children with TIDM from the Department of Endocrinology in 15 hospitals were selected, including the First Affiliated Hospital of Henan University of Science and Technology and other tertiary hospitals in Henan province. All patients were younger than 14 years old and treated with either continuous subcutaneous insulin infusion (CSII) or multiple daily insulin injection (MDI). All patients wore FGMS for 2 weeks after the selection. Various glucose monitoring indicators and adverse events were recorded during the application of FGMS, and the effects of diabetes duration, insulin injection model and other factors on blood glucose control were also analyzed. The t test, analysis of variance and rank sum test were used to compare the differences between groups, the correlation was analyzed by partial correlation.
ResultsThe baseline glycated hemoglobin A1c (HbA1c) was (8.3±1.7)%. During the application of FCMS, the estimated HbA1c was (7.8±1.3)%, the mean blood glucose was (9.8±2.1) mmol/L, and the percentage of time of blood glucose reaching the target (3.9-7.8 mmol/L) was (37±14)%. The percentage of time of hypoglycemia (<3.9 mmol/L) was 4% (3, 8)%. The standard deviation of blood glucose (SDBG) was (4.1±1.2) mmol/L and the mean amplitude of glycemic excursion (MAGE) was (8.4±2.5) mmol/L. The SDBG and MAGE in CSII group were decreased compared with MDI group (t=2.65, 2.51, both P<0.05). The partial correlation analysis showed that the SDBG as well as the MAGE was positively correlated with the baseline HbA1c (r=0.401, 0.357, both P<0.05). No adverse events related to FGMS was recorded during the study period. The drop rate of FGMS sensors was decreased significantly in winter.
ConclusionT1DM patients under 14 years old in Henan province have a high HbA1c level, a high risk of hypoglycemia and a large fluctuation of blood glucose. The application of FGMS in children is safe. It may be helpful to reduce the drop of the sensor by avoiding the exposure of FGMS sensors.
Key words:
Diabetes mellitus, type 1; Child; Flash glucose monitoring; Glycemic variability
Contributor Information
Jinlei Bai
Luoyang Clinical Medicine Research Center of Endocrine and Metabolic Diseases
Department of Endocrinology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China
Yujin Ma
Liping Li
Liujun Fu
Jie Liu
Keyan Hu
Haiyan Wei
Junhong Wang
Xiangyang Guo
Xiuqin Geng
Min Chen
Dezeng Tian
Yafei Shen
Junhang Tian
Haixia Wu
Yahui Mu
Wenbo Jin
Juzhen Zhao
Lianwei Wang
Zhigang Zhao
Hongyun Wang
Hongwei Jiang
