Value of CT hyperenhancement sign in diagnosis and differential diagnosis of benign and malignant nodules in thyroid
Zhijiang Han, Yanyan Shu, Wenhui Chen, Jingjing Xiang, Dingcun Luo, Xufeng Lai
Published 2015-08-25
Cite as Chin J Endocr Surg, 2015, 09(4): 295-297,301. DOI: 10.3760/cma.j.issn.1674-6090.2015.04.009
Abstract
ObjectiveTo assess the value of CT hyperenhancement sign in diagnosis and differential diagnosis of benign and malignant thyroid nodules.
MethodsCT findings of 2926 nodules in 1676 patients were retrospectively analyzed, among which 2174 nodules were benign and 752 nodules were malignant. All the patients had pathological diagnosis. The degrees of enhancement were divided into hyperenhancement and iso/hypoenhancement. The distribution of hyperenhancement in benign and malignant nodules were summarized. The sensitivity, specificity, positive and negative predictive value and accuracy of hyperenhancement for benign nodules and adenomatoid nodules were observed.
ResultsHyperenhancement was more common in benign nodules than in malignant nodules(10.3% vs 0.7%, χ2=70.259, P<0.05), and its sensitivity, specificity, positive and negative predictive value and accuracy was 9.8%, 99.5%, 98.2%, 27.6% and 32.8%, respectively. Hyperenhancement was more common in adenomatoid nodules than in nonadenomatoid benign nodules(67.4% vs 6.1%, χ2=525.025, P<0.05), and its sensitivity, specificity, positive and negative predictive value and accuracy was 67.4%, 93.9%, 41.6%, 97.8% and 92.3%, respectively.
ConclusionHyperenhancement sign is an important sign which can effectively differentiate benign nodules from malignant nodules, and adenomatoid nodules from nonadenomatoid benign nodules, and it is helpful for diagnosis of benign nodules and adenomatoid nodules.
Key words:
Thyroid nodule; Thyroid neoplasm; Computed tomography
Contributor Information
Zhijiang Han
Department of Radiology, First People's Hospital of Hangzhou, Hangzhou 310006, China
Yanyan Shu
Wenhui Chen
Jingjing Xiang
Dingcun Luo
Xufeng Lai
