To analyze the clinical data of patients with Cushing's syndrome(CS)and to understand the relationship between glucose metabolism and CS.

Oral glucose tolerance test(OGTT), the level of insulin, body mass index(BMI), 24-hour urinary free cortisol(24h UFC), family history of diabetes in patients with CS were retrospectively analyzed.

The course of disease in patients of CS complicated with diabetes mellitus(CS/DM)group was longer than CS complicated with impaired glucose tolerance(CS/IGT)and CS complicated with normal glucose tolerance(CS/NGT)group. 66.67% of patients with CS/NGT have insulin resistance. Logistic regression analysis indicated that age, course of disease, midnight plasma cortisol were risk factors of CS induced diabetes mellitus. CS/DM group had higher proportion of family history of diabetes. 24h UFC and BMI had no significant differences among the three groups(P>0.05).

Age, course of disease, midnight plasma cortisol are risk factors of CS induced diabetes mellitus. OGTT and insulin level determination are necessary for diagnosis and intervention treatment at the early stage.

Cushing's syndrome; Diabetes; Impaired glucose tolerance(IGT)