Correlative studies of ultrasonic classification diagnosis and clinicopathological features of thyroid calcification lesions
Yi Zhang, Mei Yuan, Shufang Zheng, Shibao Fang, Yujun Li, Wenhai Sun
Published 2016-02-25
Cite as Chin J Endocr Surg, 2016, 10(1): 13-18. DOI: 10.3760/cma.j.issn.1674-6090.2016.01.004
Abstract
ObjectiveTo investigate correlative relations between the ultrasonic classification diagnosis and the clinicopathological features of thyroid calcification lesions.
MethodsThe clinical data of 198 cases diagnosed as thyroid calcification lesions by ultrasonic, surgery and pathology were retrospectively analyzed. Spearman method was used to analyze the relationship of TCL ultrasonic diagnosis, clinical pathological traits and the classification of differentiated thyroid carcinoma (DTC).
ResultsAmong the 198 TCL cases, ultrasonic diagnosis and pathologic diagnosis were accordant in 178 (90.40%)cases. Among 119 (60.10%)cases of thyroid carcinoma (TC), 101 cases (84.87%)were papillary carcinoma, 11 cases (9.24%)were follicular carcinoma, 5 cases (4.20%) were medullary carcinoma and 2 cases (1.68%)were anaplastic carcinoma. Among 79 cases (39.90%)of benign lesions, 34 cases (43.04%)were adenoma, 27 cases (34.18%)were nodular goiter, and 18 cases (22.78%)were hashimoto's thyroiditis (HT). Calcified classification were as following: 74 cases (37.37%)were typeⅠa and 4 cases (2.02%) were typeⅠb (both were TC); 20 cases (10.10%)were typeⅠc, among which 19 cases were nodular goiter, and 1 case was TC. Among the 37 cases (23.74%)of typeⅡ, 28 cases were TC, and 19 cases were benign lesions. Among the 20 cases (10.10%)of type Ⅲ, 8 cases were TC, and 12 cases were benign lesions.Among 22 cases (11.11%)of type Ⅳ, 2 cases were TC, and 20 cases were benign lesions. Among 11 cases (5.56%)of type Ⅴpatients, 2 cases were TC, and 9 cases were benign lesions. The rate of TC with cervical metastasis was 41.18%(49/119). 68.91%(82/119)of carcinoma nodules were grade Ⅱ-Ⅲ in color Doppler flow imaging (CDFI),grade 0-Ⅰwere mainly benign nodules, and grade Ⅲ with mussy blood flow in CDFI were HT.
ConclusionsType Ⅰa andⅠb micro calcification is the pathological basis of ultrasonic diagnosis of papillary thyroid carcinoma and follicular carcinoma, which is closely related to DTC. Calcified isolation nodule of typeⅡand Ⅲ with levelⅡ-Ⅲ bleeding is a risk factor for TC. TypeⅠc, Ⅲ, Ⅳ and Ⅴcalcification is closely related to benign TCL. CDFI has important value for identifying benign and malignant CLT.
Key words:
Thyroid calcification lesions; Ultrasonic diagnosis and typing; Thyroidcarcinoma; Clinical pathology
Contributor Information
Yi Zhang
Department of Ultrosound, Health Examination Center, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
Mei Yuan
Department of Ultrosound, Health Examination Center, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
Shufang Zheng
Department of Ultrosound, Health Examination Center, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
Shibao Fang
Department of Ultrosound, Health Examination Center, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
Yujun Li
Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
Wenhai Sun
Department of Thyroid, the Affiliated Hospital of Qingdao University, Qingdao 266003, China
