The Value of computed tomgraphy in differential diagnosis between medullar thyroid carcinoma and papillary thyroid carcinoma
Zhijiang Han, Jinwang Ding, Wenhui Chen, Dingcun Luo, Hua Zhang, Yanyan Shu
Published 2016-02-25
Cite as Chin J Endocr Surg, 2016, 10(1): 9-12,18. DOI: 10.3760/cma.j.issn.1674-6090.2016.01.003
Abstract
ObjectiveTo assess the value of computed tomgraphy (CT) in differential diagnosis between medullar thyroid carcinoma (MTC)and papillary thyroid carcinoma (PTC).
MethodsCT findings of 20 lesions in 16 MTC patients and 35 lesions in 35 PTC patients were retrospectively analyzed. All patients were confirmed by pathology exam. We investigated the shape, location, bitten cookie sign, calification and lymph node metastasis between the two groups of patients to summarize the sensitivity and specificity of regular shape for MTC or lesions located in lower thyroid lobe, bitten cookie sign, lymph node metastasis for PTC.
ResultsRegular shape was more common in MTC patients than in PTC patients (χ2=5.815,P=0.016), with sensitivity and specificity of 55% and 77.1% respectively. Lesions were located at lower thyroid (χ2=10.732,P=0.001), bitten cookie sign (χ2=18.832,P= 0.000) and lymph node metastasis (χ2=4.377,P=0.036)was significantly more common in PTC patients than in MTC patients, with sensitivity and specificity of 40%(14/35) and 100%(16/16), 80%(28/35) and 80% (16/20), and 68.6% (24/35) and 62.5%(10/16) respectively. Calcification was not significantly different between MTC and PTC patients (χ2=0.550,P=0.458).
ConclusionsCT plays an important role in differential diagnosis between MTC and PTC. Regular shape is helpful for the diagnosis of MTC. Leisions located at lower thyroid, with bitten cookie sign and lymph node metastasis are conductive to the diagnosis of PTC.
Key words:
Medullar thyroid carcinoma; Papillary thyroid carcinoma; Tomography; X-ray computed
Contributor Information
Zhijiang Han
Department of Radiology, Hangzhou First People's Hospital, Hangzhou 310006, China
Jinwang Ding
Department of Oncological Surgery, Hangzhou First People's Hospital, Hangzhou 310006, China
Wenhui Chen
Department of Radiology, Hangzhou First People's Hospital, Hangzhou 310006, China
Dingcun Luo
Department of Oncological Surgery, Hangzhou First People's Hospital, Hangzhou 310006, China
Hua Zhang
Department of Radiology, Ruijin Hospital, School of Medical, Shanghai Jiaotong University, Shanghai 200025, China
Yanyan Shu
Department of Radiology, People's Hospital of Hangzhou, Xiaoshan Area, Hangzhou 311200, China
