Original Article
The influence of oral administration of glucose before surgery on insulin resistance and oxidative stress in castric cancer patients undergoing surgery
Jin Yude, Zhu Wei, Dai Chuang, Yu Hongbin, Wang Zongli, Xu Yongqiang
Published 2017-06-25
Cite as Chin J Endocr Surg, 2017,11(03): 210-214. DOI: 10.3760/cma.j.issn.1674-6090.2017.03.009
Abstract
ObjectiveTo explore the influence of oral administration of glucose before surgery on insulin resistance and oxidative stress in castric cancer patients undergoing surgery.
Methods63 cases of castric cancer patients undergoing surgery were divided into observation group (n=32) and the control group (n=31) according to random number table method. Patients were given fasting after ten o’clock the day before surgery. Patients in the observation group were dealed with 500 ml 100 g/L glucose solution orally, while patients in the control group were dealed with the same amount of distilled water 3 hours before surgery. The general information and operation indicators were recorded. Blood glucose (GLU) , insulin, malondialdehyde (MDA) and superoxide dismutase (SOD) levels were detected before surgery and 4 hours after surgery. Insulin resistance index (HOMA-IR) was recorded also.
ResultsThe general data between the two groups before the test started had no statistically significant difference (P>0.05) . All patients completed test successfully, and the complications such as choking cough, aspiration did not happen during the treatment. The operation time, Intraoperative fluid infusion, intraoperative blood loss and postoperative pathological stage between the two groups had no statistical difference (P>0.05) . GLU, insulin and HOMA-IR in the two groups after surgery increased significantly than those before surgery, and the difference had statistical significance (P<0.05) . GLU, insulin and HOMA-IR were significantly lower in the observation group than in the control group, and the difference had statistical significance (P<0.05) . SOD and MDA in the two groups after surgery increased significantly than those before surgery, and the difference had statistical significance (P<0.05) . SOD in the observation group was significantly higher, while MDA was significantly lower than those in the control group, and the difference had statistically significance (P<0.05) .
ConclusionOral administration of glucose before surgery in castric cancer patients undergoing surgery can reduce insulin resistance and oxidative stress, and it is safe.
Key words:
Carbohydrates; Gastric cancer; Surgery; Insulin resistance; Oxidative stress
Contributor Information
Jin Yude
Department of Gastrointestinal Surgery, Huzhou First People’s Hospital, Huzhou 313000, China
Zhu Wei
Department of Oncology, Huzhou First People’s Hospital, Huzhou 313000, China
Dai Chuang
Department of Gastrointestinal Surgery, Huzhou First People’s Hospital, Huzhou 313000, China
Yu Hongbin
Department of Gastrointestinal Surgery, Huzhou First People’s Hospital, Huzhou 313000, China
Wang Zongli
Department of Gastrointestinal Surgery, Huzhou First People’s Hospital, Huzhou 313000, China
Xu Yongqiang
Department of Gastrointestinal Surgery, Huzhou First People’s Hospital, Huzhou 313000, China
