Original Article
A meta-analysis on surgical treatment of chronic pancreatitis: duodenum-preserving pancreatic head resec-tion versus pancreaticoduodenectomy
Yonghui Sun, Xiaojing Zhang, Hai Lin, Xinli Gong, Bingzheng Yan, Jiaqi Xu, Qilong Chen
Published 2019-06-25
Cite as Chin J Endocr Surg, 2019, 13(3): 249-255. DOI: 10.3760/cma.j.issn.1674-6090.2019.03.017
Abstract
ObjectiveTo carry out a meta-analysis, in order to evaluate the effectiveness and safety of the duodenum-preserving pancreatic head resection (DPPHR) and pancreaticoduodenectomy (PD) or pylorus-preserving pancreaticoduodenectomy (PPPD) for surgical treatment of chronic pancreatitis.
MethodsMedline, EMBASE, Cochrane library and other medical databases were searched for the clinical trials (randomized controlled trials) of comparing DPPHR Versus PD/PPPD. A total of 5 clinical trials (8 references) met the inclusion criteria. The data were analyzed using the RevMan 5.3 software.
ResultsThe two methods don’t have statistical difference in terms of operation time (P=0.007) , postoperative morbidity (P=0.35) and mortality (P=0.18) , pain relief (P=0.36) , new onset of diabetes (P=0.11) , exocrine insufficiency (P=0.18) , short-term (P=0.14) and long-term (P=0.16) quality of life score, the length of hospital stay (P=0.69) , and pancreatic fistula (P=0.78) . Weight gain (P<0.000 01) and occupational rehabilitation (P=0.03) were significantly improved in the DPPHR group. However, PD/PPPD group was associated with fewer readmission due to pancreatic diseases.
ConclusionsDPPHR offers more advantages with regard to the quality of life. However, it needs more high-quality clinical trials to verify the results.
Key words:
Chronic pancreatitis; Pancreaticoduodenectomy; Duodenum-preserving pancreatic head resection; Meta-analysis
Contributor Information
Yonghui Sun
Digestion and Vascular Center, Department of Pancreas Surgery, the First Affiliated Hospital to Xinjiang Medical University, Urumqi 830054, China
Xiaojing Zhang
Department of Anesthhesiology, the First Affiliated Hospital to Xinjiang Medical University, Urumqi 830054, China
Hai Lin
Digestion and Vascular Center, Department of Pancreas Surgery, the First Affiliated Hospital to Xinjiang Medical University, Urumqi 830054, China
Xinli Gong
Digestion and Vascular Center, Department of Pancreas Surgery, the First Affiliated Hospital to Xinjiang Medical University, Urumqi 830054, China
Bingzheng Yan
Digestion and Vascular Center, Department of Pancreas Surgery, the First Affiliated Hospital to Xinjiang Medical University, Urumqi 830054, China
Jiaqi Xu
Digestion and Vascular Center, Department of Pancreas Surgery, the First Affiliated Hospital to Xinjiang Medical University, Urumqi 830054, China
Qilong Chen
Digestion and Vascular Center, Department of Pancreas Surgery, the First Affiliated Hospital to Xinjiang Medical University, Urumqi 830054, China
