Objective To investigate the influence of rhGH on blood sugar andprotein synthesis in severe burn patients. Methods 24 severe burn patients were enrolled in this study.The rhGH was administered subcutaneously in the dose of 0.2～0.25 IU/kg*d-1 at 10pm every day for 10 to 14 days.Serum total pertein,albumin and blood sugar concentrations were determined and analyzed before treatment with rhGH and after. Results Serum total protein and albumin levels were sygnificantly increased of the rhGH provided than before and placebo control in the same stage.The bolld sugar level was enhanced in 2 weeks after burn injury,especially in a week after burn injury.The incidences of hyperglycemia were 52.38% in 3 days after burn injury,50.00% in a week nd 20.00% in two weeks in severe burn patients.When rhGH was administered in a week,two weeks and more than two weeks after burn injury,the incidences of hyperglycemia were 100%,50% and 0% respectively. Conclusions The rhGH could promote protein synthesis in severe burn patients.The rhGH could cause blood sugar increasing in early stage after burn injury,so it was in good time that the rhGH was provided rof severe burn patients during more than two weeks after burn injury.