Original Article
Relationship of MTNR1B DNA methylation with gestational diabetes and gestational glucose and lipid metabolism features
Jiapei Li, Weigang Zhao, Yong Fu, Yingyue Dong, Juan Li, Juntao Liu
Published 2019-06-30
Cite as Chin J Clin Nutr, 2019, 27(3): 138-143. DOI: 10.3760/cma.j.issn.1674-635X.2019.03.003
Abstract
ObjectiveTo explore the relationship of MTNR1B DNA methylation with gestational diabetes and gestational glucose and lipid metabolism features.
Methods50 patients with gestational hyperglycemia, diagnosed by 100 g oral glucose tolerance test(OGTT) during mid-trimester were selected between 2009 and 2012. 50 pregnant women with normal glucose tolerance of matched age and body mass index were included in the control group. The blood samples during mid-trimester and the clinical parameters were collected. MTNR1B DNA methylation levels were measured.
ResultsAfter adjusting age and body mass index, the CpG locus located at + 64 bp away from the translation initiation site of MTNR1B was related with gestational diabetes (OR=0.859, 95% CI: 0.772-0.955, P=0.005). DNA methylation level of several MTNR1B loci was also related with gestational glucose and lipid metabolism features.
ConclusionMTNR1B DNA methylation is related with gestational diabetes and gestational glucose and lipid metabolism.
Key words:
MTNR1B DNA methylation; Gestational diabetes mellitus; Gestational glucose and lipid metabolism
Contributor Information
Jiapei Li
Department of Endocrinology, Peking Union Medical College Hospital, CAMS &
PUMC, Beijing 100730, China
Weigang Zhao
Yong Fu
Yingyue Dong
Juan Li
Juntao Liu
