Original Article
Effect of vitamin D intervention on the outcome of glucose metabolism in patients with impaired glucose regulation
Jingjing Lu, Yeqing Liu, Jie Zhang, Pingping Lou, Yan Liu, Yaru Zhou
Published 2019-12-30
Cite as Chin J Clin Nutr, 2019, 27(6): 349-353. DOI: 10.3760/cma.j.issn.1674-635X.2019.06.004
Abstract
ObjectiveTo explore the intervention effect of low-dose vitamin D on glucose metabolism of patients with impaired glucose regulation.
MethodsA total of 196 subjects receiving oral glucose tolerance test were enrolled in this study, including individuals with normal glucose tolerance (NGT group, n=67) and individuals with impaired glucose regulation (IGR group, n=129). The IGR group was divided into intervention group (n=64)and non-intervention group (n=65) according to vitamin D intervention (for 1 year) performed or not. Clinical data and biochemical parameters were collected.
ResultsThe level of serum 25(OH)D3 was significantly lower in the IGR group than that of normal control group (P<0.05). After 1 year of low-dose vitamin D intervention, insulin sensitivity increased and insulin resistance decreased in the intervention group as compared with non-intervention group. Diabetes developed less frequently in the intervention group (25 of 64 [39.1%]) compared with non-intervention group (30 of 65 [46.2%]). But there was no significant different in diabetes prevalence between the two groups.
ConclusionsVitamin D intervention can improve insulin sensitivity and reduce insulin resistance in patients with impaired glucose regulation. Low dose vitamin D can improve the abnormal glucose metabolism outcome in patients with impaired glucose regulation.
Key words:
vitamin D; 25(OH)D3; type 2 diabetes mellitus; insulin secretion
Contributor Information
Jingjing Lu
Departmentof Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
Yeqing Liu
Jie Zhang
Pingping Lou
Yan Liu
Yaru Zhou
