Objective To investigate the effect of age on the development of refractive changes in children with accommodative esotropia after wearing glasses with a follow-up study based on clinical exams and spectacle wear. Methods In this retrospective study, 65 children with accommodative esotropia were examined once every 2-4 months with retinoscopy without cycloplegia for 1-7 consecutive years.A paired t test was used to compare the refractive differences between the dominant eye and non-dominant eye,linear regression curve was used to analyze the data comparing refraction and the timeline of the observation period.Results There was a linear regression between the changes of spherical equivalent refraction,spherical refraction,cylinder refraction and age (P＜0.01).The spherical equivalent refraction of the dominant eye and non-dominant eye with accommodative esotropia showed a decrease of 0.015 D and 0.012 D per month,respectively.Overall, the change in hyperopic spherical equivalent first increased and then decreased. There was a gradual trend toward myopia.Astigmatism was nearly constant.The change age was 3.58～4.90 year old during the study.The monthly average rate of change in the development of astigmatism was only 0.002 D.Conclusion The development of refractive changes in children with accommodative esotropia after wearing glasses first showed a change in the direction of hyperopia, then in the direction of emmetropization.The average annual rate of change was less than 0.25 D.