Original Article
The Health Benefits of Yiqiqufengzhitong Granules to Alleviate the Symptoms of Ocular Discomfort Experienced of Patients after Transepithelial Photorefractive Keratectomy
Mengmeng Deng, Yueqiang Zhang, Hua Li, Lianrong Yin
Published 2019-01-25
Cite as Chin J Optom Ophthalmol Vis Sci, 2019, 21(1): 65-70. DOI: 10.3760/cma.j.issn.1674-845X.2019.01.012
Abstract
Objective:To evaluate the efficacy of alleviating postoperative ocular symptoms with yiqiqufengzhitong granules after transepithelial photorefractive keratectomy (TPRK).
Methods:This was a verifiably randomized and controlled study. Fifty-two patients (102 eyes) who had undergone TPRK surgery at the Eye Hospital of China Academy of Chinese Medical Sciences from June 2015 to April 2017 were selected. Patients were randomly divided into a Chinese medicine group (26 patients, 50 eyes) and a control group (26 patients, 52 eyes). Conventional eye drops were used in the control group and the Chinese medicine group was treated with conventional eye drops combined with granules. The treatment period lasted for 7 days. Patients’ uncorrected visual acuity, symptom scores, corneal fluorescence, intraocular pressure and central corneal epithelial thickness were measured on the first, third, fifth and seventh days after surgery. The measurement data were analyzed by repeated measured analysis of variance, t-test and chi-square test.
Results:The symptom scores for the Chinese medicine group were better than scores for the control group (P<0.001). And uncorrected visual acuity was better than acuity in the control group on the first, third, and fifth days (P<0.05). On the fifth day,the recovery of the corneal epithelium in the Chinese medicine group was proportionately higher than in the control group (χ2=4.003, P=0.045). The central corneal epithelium was thinner in the Chinese medicine group on the seventh day after surgery than in the control group (t=2.082, P=0.042). And the difference on the seventh day after surgery was not statistically significant compared with that before surgery in the Chinese medicine group (t=-1.191, P=0.245). On the seventh day after surgery, the changes in intraocular pressure between the groups and the difference between postoperative and preoperative pressure in the two groups were not significant (P>0.05).
Conclusions:Yiqiqufengzhitong granules can alleviate symptoms of postoperative discomfort effectively, promote corneal epithelial recovery and uncorrected visual acuity recovery. There is no adverse effect on intraocular pressure.
Key words:
transepithelial photorefractive keratectomy; pain; self-conscious symptoms; yiqiqufengzhitong granules
Contributor Information
Mengmeng Deng
Department of Ophthalmology, Beijing Rectum Hospital, Beijing Erlonglu Hospital, Beijing 100120, China
Yueqiang Zhang
Department of Refractive Surgery, Eye Hospital of China Academy of Chinese Medical Sciences, Beijing 100040, China
Hua Li
Department of Refractive Surgery, Eye Hospital of China Academy of Chinese Medical Sciences, Beijing 100040, China
Lianrong Yin
Department of Refractive Surgery, Eye Hospital of China Academy of Chinese Medical Sciences, Beijing 100040, China
