Clinical Science
Clinical effect of 0.01% atropine eye drops on myopia progression in school-age children
Junbo Rong, Aicun Fu, Yong Lyu, Bingxin Zhao, Weiqun Wang, Junjie Zhang
Published 2020-06-10
Cite as Chin J Exp Ophthalmol, 2020, 38(6): 494-498. DOI: 10.3760/cma.j.cn115989-20200329-00223
Abstract
ObjectiveTo evaluate the clinical efficacy of 0.01% atropine eye drops in the control of myopia progression in Chinese children with myopia.
MethodsA prospective non-randomized controlled study was performed.The 152 myopic children aged 6 to 14 years were enrolled from June to October in 2016 in the First Affiliated Hospital of Zhengzhou University, the subjects wore single-vision spectacle lenses (SV) to correct refractive errors and were divided into two groups: the eyes in the atropine group (n=72) were treated with one drop of 0.01% atropine eye drops before sleep; the eyes in the simple SV group (n=80) only wore SV.Repeated measurements of refractive power and axial length were performed at baseline, 4, 8 and 12 months after treatment.Discomfort symptoms were also observed.Informed consent was provided according to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Zhengzhou University.
ResultsAfter 12 months of treatment, the progression of myopia in the atropine group was (0.46±0.42)D, which was significantly lower than (0.70±0.42)D in the simple SV group (t=5.479, P<0.001). The increase of axial length in the atropine group was (0.36±0.21)mm, which was significantly lower than (0.46±0.41)mm in the simple SV group (t=9.883, P=0.004). The proportions of myopia progressed more than 0.50 D per year were 45%(28/70)and 28%(19/80) in the atropine group and simple SV group, respectively, with a significant difference between the two groups (χ2=7.582, P=0.035). In the atropine group, photophobia appeared in 16 cases (22.9%), and was gradually relieved.Allergy was observed in 1 case and disappeared after atropine withdrawal.
ConclusionsApplication of 0.01% atropine eye drops can effectively control the progression of myopia and have few discomfort symptom in Chinese myopic children.
Key words:
Myopia; Children; Atropine; Axial length of eye; Therapeutic effect
Contributor Information
Junbo Rong
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Aicun Fu
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Yong Lyu
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Bingxin Zhao
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Weiqun Wang
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Junjie Zhang
Department of Ophthalmology, Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Zhengzhou 450003, China
