Original Article
Efficacy of postoperative medication in the treatment of cataract with uveitis
Shengwei Wu, Ran Sun, Jian Zhang, Yuefeng Pan, Ge Shi
Published 2019-05-25
Cite as Chin J Ocul Traum Occupat Eye Dis, 2019, 41(5): 337-343. DOI: 10.3760/cma.j.issn.2095-1477.2019.05.004
Abstract
ObjectiveTo evaluate the efficacy of postoperative application of diclofenac sodium combined with triamcinolone acetonide in the treatment of cataract with uveitis.
MethodsThe data of 85 patients of cataract with uveitis from Jan. 2016 to Jun. 2018 in Luhe Hospital were studied retrospectively.According to the random number table, all patients were divided into the observation group and the control group.The two groups were performed phacoemulsification and intraocular lens implantation.The control group, 40 cases, received injection of triamcinolone subconjunctival postoperatively, and treated with Tobramycin and Dexamethasone ophthalmic suspension eye drops after injection.The observation group, 45 cases, received diclofenac sodium eye drops on the basis of eyes drops of the control group.The course of medication was 1 month. The changes after treatment were compared between the two groups.
ResultsThe aqueous humor sCD44, TGF-β2 and MCP-1 in the observation group at 1 month after treatment were significantly better than those in the control group (P<0.05). There was no significant difference in intraocular pressure between the two groups after treatment (P>0.05). In the observation group, the visual acuity, the incidence of grade 0 anterior chamber reaction, the total incidence of corneal edema, macular edema and photophobia were significantly better than those in the control group (P<0.05). The difference in the incidence of adverse reactions was not significant between the two groups during medication (P>0.05).
ConclusionApplication of Diclofenac sodium combined with triamcinolone acetonide is effective for cataract with uveitis, can reduce the aqueous humor sCD44, TGF-β2 and MCP-1 levels, alleviate anterior chamber reaction, and reduce the complications.
Key words:
Cataract; Uveitis; Phacoemulsification; Triamcinolone acetonide; Factor, aqueous humor
Contributor Information
Shengwei Wu
Department of Ophthalmology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China
Ran Sun
Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Jian Zhang
Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Yuefeng Pan
Department of Ophthalmology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China
Ge Shi
Department of Ophthalmology, Medical College of Nantong University, Jiangsu 226001, China
