Musculoskeletal Ultrasound
Application of superb microvascular imaging in detection of blood flow in gout
Lu Beilei, Huang Beijian, Li Cuixian, Zheng Fengyang, Wang Wenping, Wang Peilei, Jing Luxia, Wang Qun
Published 2020-04-01
Cite as Chin J Med Ultrasound(Electronic Edition), 2020,17(04): 353-358. DOI: 10.3877/cma.j.issn.1672-6448.2020.04.011
Abstract
ObjectiveTo assess the application of superb microvascular imaging (SMI) in detecting blood flow in tophi and synovial hyperplasia.
MethodsA total of 68 non-acute gout patients were enrolled at Zhongshan Hospital of Fudan University from October 2017 to October 2018. The blood flow signals in tophi and synovial hyperplasia were detected by power Doppler imaging (PDI) and SMI respectively, and they were divided into four grades (0~3). The differences of blood flow grades detected in tophi and synovial hyperplasia by SMI and PDI were compared, and the correlation between blood flow grades and high-sensitivity C-reactive protein (hs-CRP) was calculated.
ResultsThere were statistically significant differences in gout duration and hs-CRP between groups with different frequency of attacks (0~5, 6~10, and >10 times/year) (P=0.006 and 0.003). The number of patients with high-grade (grades 2 and 3) tophi and synovial hyperplasia detected by SMI was significantly more than that by PDI, and the number of patients with low-grade (grades 0 and 1) was significantly less than that by PDI (Z=-5.385 and -2.842, respectively; P<0.001, =0.004). The SMI grade of synovial hyperplasia had the highest correlation with hs-CRP (r=0.721, P<0.001), followed by synovial hyperplasia grade, PDI grade of synovial hyperplasia, SMI grade of tophi, and PDI grade of tophi (r=0.570, 0.563, 0.532, and 0.399, respectively; P<0.001, <0.001, <0.001, and =0.007, respectively).
ConclusionSMI is more sensitive in detecting blood flow in tophi and synovial hyperplasia than PDI. SMI grade of synovial hyperplasia has the highest correlation with hs-CRP, which can provide more valuable diagnostic information for gout activity assessment.
Key words:
Gout; Ultrasonography; Microvascular imaging; Synovial hyperplasia; Tophus
Contributor Information
Lu Beilei
Department of Ultrasound, Zhongshan Hospital of Fudan University & Shanghai Institute of Medical Imaging, Shanghai 200032, China
Huang Beijian
Department of Ultrasound, Zhongshan Hospital of Fudan University & Shanghai Institute of Medical Imaging, Shanghai 200032, China
Li Cuixian
Department of Ultrasound, Zhongshan Hospital of Fudan University & Shanghai Institute of Medical Imaging, Shanghai 200032, China
Zheng Fengyang
Department of Ultrasound, Zhongshan Hospital of Fudan University & Shanghai Institute of Medical Imaging, Shanghai 200032, China
Wang Wenping
Department of Ultrasound, Zhongshan Hospital of Fudan University & Shanghai Institute of Medical Imaging, Shanghai 200032, China
Wang Peilei
Department of Ultrasound, Zhongshan Hospital of Fudan University & Shanghai Institute of Medical Imaging, Shanghai 200032, China
Jing Luxia
Department of Ultrasound, Zhongshan Hospital of Fudan University & Shanghai Institute of Medical Imaging, Shanghai 200032, China
Wang Qun
Department of Ultrasound, Zhongshan Hospital of Fudan University & Shanghai Institute of Medical Imaging, Shanghai 200032, China
