Review
Progress in research of L1CAM in early endometrial carcinoma
Qingmin Wang, Xianghua Yin
Published 2017-07-01
Cite as Chin J Clinicians(Electronic Edition), 2017, 11(13): 2002-2005. DOI: 10.3877/cma.j.issn.1674-0785.2017.13.009
Abstract
L1 cell adhesion molecule (L1CAM) is a kind of cell adhesion molecule consisting of a series of protein domains, playing an important role in the regulation of nerve cell movement and growth. Studies show that L1CAM expressed in tumor cells can promote cell proliferation, migration, invasion, and metastasis, which affects the prognosis of patients with tumors. Recently, some researchers have detected L1CAM expression in early endometrial carcinoma tissue by immunohistochemistry and analyzed the adverse influence of L1CAM on the prognosis of patients with endometrial carcinoma. This article discusses the mechanism of L1CAM in tumor cell metastasis, especially the relationship between L1CAM and epithelial-mesenchymal transition (EMT), and its influence on the prognosis of patients with endometrial cancer, in order to further explore the adverse prognostic factors of endometrial carcinoma and provide evidence for more precise treatment of this malignancy.
Key words:
Endometrial cancer; L1CAM; EMT; Lymphatic metastasis; Prognosis
Contributor Information
Qingmin Wang
Department of Gynecology and Obstetrics, Dlian Medical University, Dalian 116044, China
Department of Gynecology and Obstetrics, Subei People′s Hospital, Yangzhou 225001, China
Xianghua Yin
Department of Gynecology and Obstetrics, Subei People′s Hospital, Yangzhou 225001, China
