Clinical Researches
Therapeutic effects of hybrid renal replacement therapy in patients with acute hyperlipidemic pancreatitis
Haipeng Shi, Yanmei Xia, Xiuzhe Wang, Xiaojing Yang, Weidong Wu, Wenjing Wu, Changwu Li, Shaowei Guan
Published 2018-02-01
Cite as Chin J Clinicians(Electronic Edition), 2018, 12(3): 138-141. DOI: 10.3877/cma.j.issn.1674-0785.2018.03.003
Abstract
ObjectiveTo evaluate the therapeutic effects of hybrid renal replacement therapy (HRRT) in patients with acute hyperlipidemic pancreatitis.
MethodsForty-two patients with HLP treated in Shanxi Dayi Hospital were enrolled into this study From June 2015 to Nov 2017. The patients were randomly divided into two groups to receive either plasma exchange (PE)/continuous veno-venous hemofiltration (CVVH; 22 patients) or CVVH alone (20 patients) for 8-12 hours. Clinical signs and symptoms, white blood cell count (WBC), C-reactive protein (CRP), serum amylase (AMY), alanine transaminase (ALT), serum creatinine (SCr), triglyceride (TG), APACHE II score, and clinical outcome were compared by paired t test or χ2test.
ResultsBefore treatment, WBC, CRP, AMY, ALT, SCr, and TG did not differ significantly between the two groups (P>0.05); after 7 days of treatment, WBC, CRP, AMY, ALT, SCr, and TG in the HP/CVVH group were significantly lower than those in the CVVH group [(12.6±3.7)×109/L vs (9.6±3.5)×109/L, t=-2.700, P=0.01; (34.7±2.2) mg/L vs (24.6±5.8) mg/L, t=-7.317, P<0.001; (819.6±89.8) IU/L vs (242.1±28.9) IU/L, t=-28.609, P<0.001; (78.9±18.) IU/L vs (56.6±5.4) IU/L, t=-5.521, P<0.001; (86.2±8.5) μmol/L vs (95.1±5.7) μmol/L, t=3.943, P<0.001; (4.1±1.6) mmol/L vs (8.9±2.1) mmol/L, t=-5.004, P<0.001]. Time to recovery of intestinal peristalsis, length of hospitalization duration, and time to disappearance of symptoms in the HP/CVVH group were significantly shorter than those in the CVVH group [(4.6±1.4) d vs (6.8±2.7) d, t=-3.36, P=0.002; (13.6±3.2) d vs (16.8±2.6) d, t=-3.535, P=0.001; (2.7±0.4) d vs (3.6±1.4) d, t=-2.891, P=0.006].
ConclusionHRRT can effectively reduce the levels of TG and inflammatory mediators and has a better therapeutic effect in patients with hyperlipidemic pancreatitis.
Key words:
Hybrid renal replacement therapy; Hyperlipidemic; Pancreatitis; Clinical research
Contributor Information
Haipeng Shi
Intensive Care Unit, Shanxi Academy of Medical Sciences, Shanxi Dayi Hospital, Taiyuan 030032, China
Yanmei Xia
Xiuzhe Wang
Xiaojing Yang
Weidong Wu
Wenjing Wu
Changwu Li
Shaowei Guan