Clinical Research
Effect of radiofrequency ablation on serum FGF-21 level and cardiac function in patients with paroxysmal atrial fibrillation
Yan Wang, Dan Xu, Liwei Liu, Yuhong Wang
Published 2018-06-15
Cite as Chin J Clinicians(Electronic Edition), 2018, 12(12): 669-672. DOI: 10.3877/cma.j.issn.1674-0785.2018.12.004
Abstract
ObjectiveTo investigate the effect of radiofrequency ablation on serum FGF-21 level and cardiac function in patients with paroxysmal atrial fibrillation.
MethodsEighty patients with paroxysmal atrial fibrillation treated at Qingdao Central Hospital from November 2015 to December 2017 were randomly divided into either a treatment group (40 cases) or a control group (40 cases). The control group was given comprehensive drug therapy, and the treatment group underwent RF ablation therapy. The two groups of patients were compared for left atrial diameter (LAD), right atrium diameter (RAD), left ventricular ejection fraction (LVEF%), and serum FGF-21 levels.
ResultsLAD and RAD were significantly smaller in the treatment group than in the control group [(36.2±7.5) mm vs (42.5±8.3) mm, t=3.586, P<0.001; (35.3±7.2) mm vs (39.4±8.1) mm, t=2.393, P=0.019], and LVEF% was significantly better in the treatment group than in the control group [(59.3±8.2)% vs (52.1±7.5)%, t=4.098, P<0.001]. Seum FGF-21 level in the treatment group was significantly lower than that of the control group [(145.2±25.6) ng/L vs (197.6±30.4) ng/L, t=4.879, P<0.001].
ConclusionRadiofrequency ablation can significantly decrease serum FGF-21 level and improve the heart function of patients with paroxysmal atrial fibrillation. Serum FGF-21 level may predict the cardiac function of patients with paroxysmal atrial fibrillation.
Key words:
Radiofrequency ablation; Paroxysmal atrial fibrillation; Fibroblast growth factor-21; Cardiac function
Contributor Information
Yan Wang
Department of Cardiology, Qingdao Central Hospital, Qingdao 266042, China
Dan Xu
Department of Cardiology, Qingdao Central Hospital, Qingdao 266042, China
Liwei Liu
Physical Examination Center, Qingdao Central Hospital, Qingdao 266042, China
Yuhong Wang
Emergency Center, Qingdao Central Hospital, Qingdao 266042, China
