Review
Progress in research of antiphospholipid antibodies in preeclampsia
Zhang Chenlu, Jiang Min, Luo Jianying
Published 2020-02-15
Cite as Chin J Clinicians(Electronic Edition), 2020, 14(2): 140-143. DOI: 10.3877/cma.j.issn.1674-0785.2020.02.013
Abstract
Antiphospholipid antibodies are a class of autoimmune antibodies that bind to phospholipids or phospholipid-binding proteins and are closely related to thrombosis and poor maternal history. Patients with high levels of antiphospholipid antibodies are prone to adverse pregnancy outcomes such as preeclampsia. Preeclampsia occurs in pregnancy and can cause multiple organ damage with severe life-threatening complications in the mother and child. The pathogenesis of preeclampsia is still not clear. Studies suggest that antiphospholipid antibodies may participate in the pathogenesis of preeclampsia by inducing oxidative stress and promoting intravascular inflammation. Early detection and early intervention for patients with antiphospholipid antibodies are essential for achieving a good pregnancy outcome.
Key words:
Antiphospholipid antibody; Preeclampsia; Neutrophil extracellular traps; Oxidative stress; Genomics; MicroRNA
Contributor Information
Zhang Chenlu
Dalian Medical University, Dalian 116044, China
Department of Obstetrics and Gynecology, Subei People’s Hospital of Jiangsu Province, Yangzhou 225001, China
Jiang Min
Clinical Medical College, Yangzhou University, Yangzhou 225009, China
Department of Obstetrics and Gynecology, Subei People’s Hospital of Jiangsu Province, Yangzhou 225001, China
Luo Jianying
Clinical Medical College, Yangzhou University, Yangzhou 225009, China
Department of Obstetrics and Gynecology, Subei People’s Hospital of Jiangsu Province, Yangzhou 225001, China