Breast Cancer•Clinical Research
Clinicopathologic characteristics of inflammatory breast cancer cases: analysis of 25 cases
Wang Wei, Xin Ling, Zhang Hong, Zhang Shuang, Xu Ling, Liu Qian, Ye Jingming, Liu Yinhua
Published 2020-05-15
Cite as Chin J Clinicians(Electronic Edition), 2020, 14(5): 332-336. DOI: 10.3877/cma.j.issn.1674-0785.2020.05.003
Abstract
ObjectiveTo investigate the clinicopathologic features and prognostic factors of inflammatory breast cancer (IBC).
MethodsWe retrospectively analyzed the clinicopathologic characteristics and outcomes of patients with IBC diagnosed at Peking University First Hospital from January 2012 to December 2018.
ResultsA total of 25 patients with IBC were included, accounting for 0.89% (25/2811) of newly diagnosed breast cancer cases at our center. All patients had complete clinicopathologic data and follow-up results. Seventeen (68%) patients had stage Ⅲ IBC, and eight (32%) had stage Ⅳ disease. The numbers of patients with luminal B (HER-2 negative), HER-2 positive, and triple-negative breast cancer were 9 (36%), 5 (20%), and 11 (44%), respectively. Nineteen patients underwent surgery, 94.7% of whom achieved local R0 resection. The median survival time was 18.2 months. The 2-year overall survival rates of patients with prognostic stage ⅢB, stage ⅢC, and stage Ⅳ disease were 72.9%, 66.7%, and 15.6%, respectively; there was a significant difference among them (χ2=13.247, P<0.001).
ConclusionIBC is a rare, aggressive disease with advanced stage and poor disease outcome. Local R0 resection can be achieved in more than 90% of patients after neoadjuvant therapy.
Key words:
Inflammatory breast cancer; Molecular subtype; Prognosis
Contributor Information
Wang Wei
Breast Cancer Center, Peking University First Hospital, Beijing 100034, China
Xin Ling
Breast Cancer Center, Peking University First Hospital, Beijing 100034, China
Zhang Hong
Department of Pathology, Peking University First Hospital, Beijing 100034, China
Zhang Shuang
Department of Pathology, Peking University First Hospital, Beijing 100034, China
Xu Ling
Breast Cancer Center, Peking University First Hospital, Beijing 100034, China
Liu Qian
Breast Cancer Center, Peking University First Hospital, Beijing 100034, China
Ye Jingming
Breast Cancer Center, Peking University First Hospital, Beijing 100034, China
Liu Yinhua
Breast Cancer Center, Peking University First Hospital, Beijing 100034, China
