Original Article
Optimal endocrine therapy for breast cancer patients in different age groups with chemotherapy-induced amenorrhea
Liang Yu, Runyi Ye, Fei He, Shiyao Sun, Ying Lin
Published 2018-12-01
Cite as Chin Arch Gen Surg(Electronic Edition), 2018, 12(6): 418-421. DOI: 10.3877/cma.j.issn.1674-0793.2018.06.012
Abstract
ObjectiveTo assess the incidence of ovarian function recovery (OFR) in women with breast cancer who were premenopausal at diagnosis and who underwent chemotherapy-induced amenorrhea (CIA) during treatment, and to explore the optimal endocrine therapy for breast cancer patients in different age groups with CIA.
MethodsThe data of one hundred and twenty-three women from January 2012 to December 2015 diagnosed with breast cancer at the First Affiliated Hospital of Sun Yat-sen University was analyzed retrospectively. The patients were divided into ≤40 years (n=35), >40 years and ≤45 years (n=34) and >45 years (n=54) subgroups. A general linear model was used to assess incidences of OFR by agesubgroups.
Results26 patients (74.29%) developed CIA in ≤40 years group. Of these, 29 patinets (82.86%) regained ovarian function within 2 years; 100% of patients in >40 to 45 years and >45 years groups developedCIA, and 17 (50.00%) and 3 (5.56%) of these regained ovarian function within 2 years, and this was significantly lower in those who were elder (χ2=24.42, 54.97, both P<0.01). In this retrospective study, 19 patients of median age 51.08 years (48.00 to 54.25 years) with hormone receptor positive high-risk breast cancer who had median 9 months (2 to 21 months) of CIA were treated with aromatase inhibitor (AI). None regained ovarian function with a median of 32 months (8 to 68 months) follow-up.
ConclusionsFor breast cancer patients with CIA age ≤45, AI should be avoided due to the high risk of OFR. For breast cancer patients age ≥51 who have at least 9 months of CIA, AI can be chosen with monitoring ovarian function regularly.
Key words:
Breast neoplasms; Amenorrhea; Chemotherapy-induced; Ovarian function tests; Aromatase; Enzyme inhibitors
Contributor Information
Liang Yu
Department of Thyroid andBreast Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Runyi Ye
Department of Thyroid andBreast Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Fei He
Departmentof Breast Surgery, Shenzhen Maternity &
Child Healthcare Hospital, Shenzhen 518028, China
Shiyao Sun
Department of Thyroid and Breast Surgery, the Second People's Hospital of Shenzhen, Shenzhen 518035, China
Ying Lin
Department of Thyroid andBreast Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China