To investigate the effect of polypoid lesions of gallbladder (PLG) and related risk factors of the disease.

The clinical data of five hundred and ten patients were retrospectively analyzed, who were diagnosed with PLG by ultrasound in the Affiliated Hospital of Southwest Medical University from March 2010 to January 2016 and followed up in the Department of Hepatobiliary Surgery.

Among the 510 patients with PLG, 293 (57.5%) had single polyp, and the follow-up time was 15 (2-58) months. The diameter of 300 (58.8%) polyps increased by 2 (1-10) mm, with an average growth rate of 0.4 mm/year. There was no change in diameter in 196 cases (38.4%), decreased in eight cases and disappeared in six cases. Univariate analysis and multivariate Logistic regression analysis showed that alcohol consumption and poor sleep quality were risk factors for PLG diameter increasing, and the difference was statistically significant (P<0.01). The drinkers were 2.615 times more likely to have an increased PLG diameter than that of non-drinkers. The risk of increasing polyps of poor sleeping subjects was 2.282 times higher than that of subjects with normal sleep.

The growth rate of PLG patients in Luzhou region is slow. Drinking alcohol and poor sleeping quality may be risk factors for gallbladder polyp growth.

Gallbladder diseases; Polyps; Risk factors; Natural history