Research Article
Coagulation and immunological indexes in children with Epstein-Barr virus infection and its clinical significance
Chengjuan Xie, Mangui Li, Qixia Ren, Ning Tang, Chenghua Liu, Shengmei Li, Huiying Ma
Published 2019-04-15
Cite as Chin J Exp Clin Infect Dis (Electronic Edition), 2019, 13(2): 162-166. DOI: 10.3877/cma.j.issn.1674-1358.2019.02.014
Abstract
ObjectiveTo investigate the changes and clinical significance of indexes of coagulation function and immune function of children infected with EB virus (EBV).
MethodsTotal of 82 children infected with EBV from February 2017 to February 2018 in Qinghai Red Cross Hospital were selected as observation group, while 82 healthy children who were examined in our hospital were selected as control group. Blood samples of enrolled cases were collected. Thrombin time (TT), prothrombin time (PT), activated partial prothrombin time (APTT) and fibrinogen (FIB) were detected and compared between the two groups by unified method, respectively. The levels of coagulation indexes such as DD dimer (D-D) and immune indexes such as IgG, IgM, IgA and CD4+ T cells were also detected, respectively.
ResultsThe levels of TT, PT and APTT of children with EBV infection were (19.31 ± 2.72) s, (15.93 ± 1.96) s and (40.43 ± 5.68) s, respectively, which were significantly longer than those of the control group [(16.65 ± 2.10) s, (13.46 ± 1.72) s, (37.15 ± 5.14) s; t = 7.010, 8.577, 3.877; all P = 0.001]. The level of FIB was also significantly lower than that of the control group [(1.17 ± 0.19) g/L vs. (1.53 ± 0.21) g/L; t = 11.511, P = 0.001], and the level of D-D dimer was significantly higher than that of the control group [(0.76 ± 0.11) mg/L vs. (0.16 ± 0.06) mg/L; t = 43.362, P < 0.001]. Compared with the control group, PLT level decreased significantly [(105.32 ± 13.54) × 109/L vs. (177.47 ± 14.27) × 109/L; t = 33.213, P < 0.001), but the levels of PDW and MPV were significantly higher than those of the control group [(30.43 ± 2.89) fL vs. (18.92 ± 3.14) fL; t = 24.423, P < 0.001. (35.13 ± 2.79) fL vs. (24.53 ± 2.36) fL; t = 26.267, P < 0.001)]. The levels of IgM [(3.68 ± 0.91) g/L], IgG [(7.75 ± 2.73) g/L] and IgA [(5.83 ± 1.46) g/L] in children with EBV infection were significantly higher than those of control group [(1.25 ± 0.28) g/L, (5.23 ± 2.16) g/L and (4.35 ± 1.18) g/L] (t = 23.112, 6.555, 7.139; all P = 0.001). The levels of complement C3 and C4 [(0.63 ± 0.26) g/L and (0.43 ± 0.18) g/L] were significantly lower than those of the control group [(1.25 ± 0.25) g/L and (0.65 ± 0.21) g/L] (t = 15.565, 7.203; both P = 0.001). Compared with the control group, the number of CD4+ T lymphocytes [(18.24 ± 4.40)% vs. (24.87 ± 5.61)%] decreased significantly, but the number of CD8+ T cells [(62.83 ± 7.21)% vs. (46.34 ± 6.45)%] of children with EBV infection increased significantly, with significant difference (t = 8.421, 15.435; both P = 0.001).
ConclusionsEBV infection could lead to coagulation dysfunction and imbalance of immune function of children, which should cause attention in clinical diagnosis and treatment.
Key words:
Epstein-Barr virus; Children; Coagulation function; Immunological function
Contributor Information
Chengjuan Xie
Clinical Lab, Qinghai Red Cross Hospital, Xining 810000, China
Mangui Li
Clinical Lab, Qinghai Red Cross Hospital, Xining 810000, China
Qixia Ren
Clinical Lab, Third People’s Hospital of Qinghai Province, Xining 810000, China
Ning Tang
Clinical Lab, Wuhan Tongji Hospital of Huazhong University of Science and Technology, Wuhan 430030, China
Chenghua Liu
Clinical Lab, Qinghai Red Cross Hospital, Xining 810000, China
Shengmei Li
Clinical Lab, Qinghai Red Cross Hospital, Xining 810000, China
Huiying Ma
Clinical Lab, Qinghai Red Cross Hospital, Xining 810000, China