To investigate the clinical characteristics and laboratory indexes of polymorphic erythematous drug eruption during the treatment of children with mycoplasma pneumoniae infection.

The clinical data of 120 children with polymorphic erythematous drug eruption during the treatment of mycoplasma pneumoniae infection in Longhua District Central Hospital, Shenzhen from March 2014 to March 2018 were collected. The clinical symptoms and signs were analyzed. Data of blood routine, electrocardiogram, renal function and myocardial enzyme were analyzed, retrospectively. Patients were given anti-inflammatory treatment for mycoplasma infection, and the efficacy and prognosis were observed.

Among the 120 children with mycoplasma pneumoniae infection, all developed diffuse erythema and macular papules [120 (100.00%)], which were significantly higher than cases with mucosal involvement [117 (97.50%)] (χ² = 3.421, P = 0.046), fever [69 (57.50%)] (χ² = 64.762, P < 0.001), headache [107 (89.17%)] (χ² = 13.744, P < 0.001), joint pain [94 (78.33%)] (χ² = 29.159, P < 0.001) and muscle pain [88 (73.33%)] (χ² = 36.923, P < 0.001), all with significant differences. The laboratory results of 120 children with mycoplasma pneumoniae infection were as follows: cases with leukocyte elevated, neutrophil elevated, eosinophil elevated, alanine aminotransferase elevated, glutamate transpeptidase elevated, total protein elevated, albumin elevated, direct bilirubin elevated, cholinesterase elevated, uric acid elevated, creatinine elevated, urea nitrogen elevated, abnormal ECG and creatine kinase elevated were 63 cases (52.50%), 46 cases (38.33%), 12 cases (10.00%), 53 cases (44.17%), 17 cases (14.17%), 30 cases (25.00%), 7 cases (5.83%), 24 cases (20.00%), 9 cases (7.50%), 23 cases (19.17%), 18 cases (15.00%), 21 cases (17.50%), 10 cases (8.33%) and 11 cases (9.17%), respectively. The temperature of 69 children with fever returned to normal within 3-7 days, and the skin lesions of 120 children subsided obviously within 3-7 days, also the blisters dried up. The shortest course of treatment of 120 children was 7 days, the longest was 51 days, and the average was 17 days. One case died of multiple organ failure due to a serious basic disease.

For children infected with mycoplasma pneumoniae, the occurrence of polymorphic erythematous drug eruption should be prevented, and drug should be suspended immediately once abnormality occurred, and specific intervention of dexamethasone and other drugs should be administrated to effectively ensure the safety of medication.

Polymorphic erythematous drug eruption; Mycoplasma pneumoniae; Infection; Clinical manifestations; Laboratory index