Original Article
Changes of oxidative stress and inflammatory factors of patients with advanced gastric cancer undergoing D2 radical gastrectomy
Qingguo Du, Fei Xue, Yansong Pu, Zhijun Mao, Dong Liu, Sida Liu, Jianhua Wang, Yanbin Long
Published 2019-12-26
Cite as Chin J Oper Proc Gen Surg(Electronic Edition), 2019, 13(6): 589-592. DOI: 10.3877/cma.j.issn.1674-3946.2019.06.015.
Abstract
ObjectiveTo compare the changes of oxidative stress, T cells and inflammatory factors of patients with advanced gastric cancer who underwent D2 radical gastrectomy.
MethodsFrom March 2016 to December 2017, clinical data of 92 patients with advanced gastric cancer were analyzed retrospectively. Fifty-one patients underwent D2 open radical gastrectomy were divided into the ORG group and 41 patients received D2 laparoscopic radical gastrectomy were divided into the LRG group. SPSS 18.0 software was used to analyze the data. Measurement data such as MDA, AOPP, T cells and the inflammatory cytokines were expressed as mean±standard deviation and were examined by independent t test. Count data such as postoperative complications were described by (n, %) and were examined by chi square test. A P value of <0.05 was considered as statistically significant.
ResultsThe levels of SOD, GSH-PX decreased and MDA and AOPP increased significantly in both two groups after operation (P<0.05). The levels of SOD and GSH-PX in LRG group were significantly higher than those in the ORG group, while the levels of MDA and AOPP in the LRG group were significantly lower than those in the ORG group respectively (P<0.05). The levels of CD4+ CD25+ Tc, IL-6, IL-8 and TNF-alpha increased significantly in both two groups (P<0.05), but the levels of CD4+ CD25+ Tc in the LRG group were significantly higher than that in the ORG group, and the levels of IL-6, IL-8 and TNF-alpha in the LRG group were significantly lower than those in the ORG group respectively (P<0.05). The average operation time of the LRG group was shorter than that of the ORG group, the average amount of bleeding was less than that of the ORG group, and the number of lymph node dissection was more than that of the ORG group, with significant difference (P<0.05). The incidence of complications was 3.9% in the ORG group and 4.9% in LRG group with no significant difference (P>0.05).
ComclusionCompared with open D2 radical operation, laparoscopic D2 radical operation has less damage, less bleeding, less oxidative stress, less inflammatory reaction and less immunosuppression, which is more conducive to the recovery of patients with advanced gastric cancer.
Key words:
Stomach neoplasms; Laparoscopes; Oxidative Stress; T-Lymphocytes; Inflammasomes
Contributor Information
Qingguo Du
Department of General Surgery, Shaanxi People’s Hospital, Shaanxi 710068, China
Fei Xue
Yansong Pu
Zhijun Mao
Dong Liu
Sida Liu
Jianhua Wang
Yanbin Long
±s)表示，采用独立t检验；术后并发症采用χ2检验，P<0.05为差异有统计学意义。
