Meta-Analysis
Diagnostic value of plasma soluble triggering receptor expressed on myeloid cells-1 for adult patients with sepsis: a meta-analysis
Hongqi Zhang, Huaying Zhao, Chao Yang, Lingwen Kong, Renfu Lu, Qingchen Wu, Dingyuan Du
Published 2019-10-01
Cite as Chin J Crit Care Med(Electronic Edition), 2019, 12(5): 328-334. DOI: 10.3877/cma.j.issn.1674-6880.2019.05.008
Abstract
ObjectiveTo investigate the diagnostic value of plasma soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a biomarker for adult patients with sepsis.
MethodsRelated studies on the diagnostic value of plasma sTREM-1 in adult patients with sepsis were searched in PubMed, Embase, Cochrane, CBM, CNKI, Wangfang and VIP published up to May 2017. The bivariate model was used to calculate the pooled diagnostic odds ratio (DOR), pooled sensitivity, pooled specificity, pooled positive likelihood ratio (PLR), and pooled negative likelihood ratio (NLR). The area under the summary receiver operating characteristic (SROC) curve was analyzed.
ResultsThirty eligible articles involving 3 349 patients were included. Meta-analysis in total population showed that the pooled DOR was 20.03 [95% confidence interval (CI) (12.20, 32.87)]; the pooled sensitivity was 0.82 [95% CI (0.77, 0.86)]; the pooled specificity was 0.81 [95%CI (0.76, 0.85)]; the pooled PLR was 4.36 [95%CI (3.37, 5.64)]; the pooled NLR was 0.22 [95%CI (0.16, 0.29)]. The SROC curve showed that the pooled AUC was 0.89 [95%CI (0.85, 0.91)].
ConclusionPlasma sTREM-1 has a moderate value in the diagnosis of adult patients with sepsis.
Key words:
Soluble triggering receptor expressed on myeloid cells-1; Sepsis; Diagnosis; Meta-analysis
Contributor Information
Hongqi Zhang
Department of Cardiothoracic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Huaying Zhao
Department of Gastroenterology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Chao Yang
Department of Burn and Plastic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Lingwen Kong
Department of Cardiothoracic Surgery, Central Hospital of Chongqing University, Chongqing Emergency Medical Center, Chongqing 400014, China
Renfu Lu
Department of Cardiothoracic Surgery, Central Hospital of Chongqing University, Chongqing Emergency Medical Center, Chongqing 400014, China
Qingchen Wu
Department of Cardiothoracic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Dingyuan Du
Department of Cardiothoracic Surgery, Central Hospital of Chongqing University, Chongqing Emergency Medical Center, Chongqing 400014, China
