Original Article
Adverse pregnant outcomes of singleton and twin pregnancies complicated with preeclampsia: A meta-analysis
Ailian Ou, Xinyue Yan, Yuwen Wen, Qitao Huang, Mei Zhong
Published 2018-02-18
Cite as Chin J Obstet Emerg(Electronic Edition), 2018, 07(1): 40-47. DOI: 10.3877/cma.j.issn.2095-3259.2018.01.009
Abstract
ObjectiveTo investigate the morbidity of perinatal and maternal outcomes in singleton and twin pregnancies complicated by preeclampsia.
MethodsPublished studies about pregnant outcomes in singleton and twin pregnancy complicated by preeclampsia were searched and screened in PubMed, Web of Science, SinoMed, Chinese Biological Medicine (CNKI), databases of Wanfang and VIP database of Chinese journal. Retrieval time from January 2000 to December 2017. The RevMan 5.3 and Stata 12.0 software were used for meta-analysis. The correlation between twin pregnancy complicated with preeclampsia and adverse pregnancy outcomes were analyze by Pooled odds ratio (OR) with 95% confidence interval (CI).
ResultsThere were 10 retrospective cohort studies, including 692 twin pregnancies complicated with preeclampsia and 3101 singleton pregnancies complicated with preeclampsia. Compared with the singleton pregnancies complicated with preeclampsia, adverse pregnant outcomes of twin pregnancies complicated with preeclampsia were increased, such as placental abruption (OR=2.16, 95%CI: 1.40-3.36), postpartum hemorrhage (OR=2.90, 95%CI: 2.03-4.15), heart failure (OR=3.73, 95%CI: 2.10-6.63), pulmonary edema (OR=2.76, 95%CI: 1.04-7.27), cesarean delivery (OR=2.27, 95%CI: 1.58-3.26), premature rupture of membrane (OR=2.99, 95%CI: 1.64-5.47), preterm delivery (OR=6.24, 95%CI: 4.16-9.38), the rates of newborn admitted to intensive care unit (OR=2.33, 95%CI: 1.66-3.26).
ConclusionCompared to the singleton pregnancies complicated with preeclampsia, twin pregnancies complicated with preeclampsia increased the morbidity of placental abruption, postpartum hemorrhage, heart failure, pulmonary edema, cesarean delivery, premature rupture of membrane, preterm and the rates of newborn admitted to intensive care unit.
Key words:
Twin pregnancy; Pre-eclampsia; Pregnancy outcome; Meta-analysis
Contributor Information
Ailian Ou
First clinical medical college of Southern Medical University, Guangzhou, 510515, China
Xinyue Yan
First clinical medical college of Southern Medical University, Guangzhou, 510515, China
Yuwen Wen
First clinical medical college of Southern Medical University, Guangzhou, 510515, China
Qitao Huang
Department of Obstetrics, Southern Hospital of Southern Medical University, Guangzhou, 510515, China
Mei Zhong
Department of Obstetrics, Southern Hospital of Southern Medical University, Guangzhou, 510515, China
