Original Article
Efficacy of ergonovine in preventing hemorrhage of cesarean section in high-risk pregnant women
Liuying Zhong, Dunjin Chen, Yanjie Ji, Gang Wang, Hongying Hou, Baoming Yin, Bingmei Dai, Weishe Zhang, Dongmei He, Ling Gao, Guifeng Ding, Qiying Zhu, Jin He, Chunxia Yin, Yin Xu, Wanli Gao, Jinying Yang
Published 2018-08-18
Cite as Chin J Obstet Emerg(Electronic Edition), 2018, 07(3): 180-184. DOI: 10.3877/cma.j.issn.2095-3259.2018.03.014
Abstract
ObjectiveTo evaluate the curative effect and safety of ergonovine in preventing bleeding during and after cesarean section in high risk pregnant women.
MethodsOne thousand and seventy-four parturients with high risk factors of bleeding who underwent cesarean section in 16 hospitals of China were collected from February to June 2017. Patients were divided into three groups according to the use of different uterine contraction agents: group I (384 cases, oxytocin plus ergonovine were injected intraoperatively, oxytocin was injected after operation), group II (340 cases, oxytocin plus ergonovine were injected intraoperatively, ergonovine was injected after operation), control group (350 cases, oxytocin was injected intraoperatively and after operation). The bleeding volume and side effects of the operation, 2 h and 24 h after operation were analyzed and compared. Analysis of variance or Chi-square test was used for statistical analysis.
ResultsIn group II, the amount of blood loss of the operation, 2 h and 24 h after operation were (400.09±203.82) ml, (31.76±27.83)ml, (60.74±55.27)ml, respectively, which were significantly less than those in group I (451.33±441.43) ml, (66.30±43.08)ml, (83.62±56.89)ml, (P<0.05). The incidence rate of the patients used uterine contraction agent in group II was 5.29% (18 cases), which was smaller than those in group I (23.18%, 89 cases) and in the control group (29.14%, 102 cases), q=3.90 and 4.32, respectively, and P less than 0.05.
ConclusionErgonovine was effective and safe for high risk pregnant women with cesarean section to prevent intraoperative hemorrhage and postoperative hemorrhage, but close attention should be paid to the adverse drug reaction.
Key words:
Ergonovine; Cesarean section; Pregnancy, high-risk
Contributor Information
Liuying Zhong
Department of Obstetrics, Third Affiliated Hospital of Guangzhou Medical University, 510150 Guangzhou, China
Dunjin Chen
Department of Obstetrics, Third Affiliated Hospital of Guangzhou Medical University, 510150 Guangzhou, China
Yanjie Ji
Department of Obstetrics and Gynecology, Dongguan Tangxia Hospital, 523721 Guangdong, China
Gang Wang
Department of Obstetrics and Gynecology, Foshan First People′s Hospital, 528000 Guandong, China
Hongying Hou
Department of Obstetrics, iBorn Women′s &
Chidren′s Hospital, 510635 Guangzhou, China
Baoming Yin
Department of Obstetrics and Gynecology, Zhuhai Maternal and Child Health Hospital, 519001 Guangdong, China
Bingmei Dai
Department of Obstetrics and Gynecology, Dongguan Maternal and Child Health Hospital, 523112 Guangdong, China
Weishe Zhang
Department of Obstetrics, Central South University Xiangya Hospital, 410008 Changsha, China
Dongmei He
Department of Obstetrics and Gynecology, BING TUAN DI SI SHI YI YUAN, 835000 Yining, China
Ling Gao
Department of Obstetrics and Gynecology, First Agricultural Division Of Xinjiang Production And Construction Corps, 843000 Aksu, China
Guifeng Ding
Department of Obstetrics and Gynecology, Maternal and Child Health Care Hospital of Xinjiang Uygur Autonomous Region 830001 Urumqi, China
Qiying Zhu
Department of Obstetrics, First Affiliated Hospital of Xinjiang Medical University, 830054 Urumqi, China
Jin He
Department of Obstetrics and Gynecology, Jilin University Bethune First Hospital, 130021 Changchun, China
Chunxia Yin
Department of Obstetrics and Gynecology, Changchun Obstetrics and Gynecology Hospital, 140052 Changchun, China
Yin Xu
Department of Obstetrics and Gynecology, Guizhou Provincial People′s Hospital, 550002 Guiyang, China
Wanli Gao
Department of Obstetrics and Gynecology, Daxing District People′s Hospital, 102600 Beijing, China
Jinying Yang
Department of Obstetrics and Gynecology, Harbin Nangang District Obstetrics and Gynecology Hospital, 150080 Harbin, China
