Review
The research progress in the mechanism of brain ischemic tolerance induced by exercise training
Zhang Feng, Dong Fang, Dong Guodong, Qin Xiaojun
Published 2018-08-05
Cite as Chin J Geriatr Orthop Rehabil(Electronic Edition), 2018,4(4): 247-251. DOI: 10.3877/cma.j.issn.2096-0263.2018.04.010
Abstract
Exercise training could alleviate the motor dysfunction following cerebral ischemia. Clinical and basic experimental study studies have explored the mechanism underlying this phenomenon. However, the exact mechanism of pre-ischemic exercise intervention on nerve damage after cerebral ischemia is still not clear, which was summarized in this review. Exercise preconditioning could reduce inflammation reaction, decrease neuron apoptosis, alleviate blood brain barrier dysfunction, improve cerebrovascular system and mitigate glutamate toxicity, thus inducing brain ischemic tolerance. The elucidation of neuroprotective effect of exercise training is helpful for implementation of exercise intervention for stroke high risk population, reducing neurological deficits following ischemic stroke, resulting in beneficial influence on the whole society.
Key words:
Rehabilitation; Brain ischemia; Exercise training
Contributor Information
Zhang Feng
Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China; Hebei Provincial Orthopedic Biomechanics Key Laboratory, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
Dong Fang
Department of Clinical Laboratory Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
Dong Guodong
No.93523 PLA Army Station Hospital, Yongji, 044500, China
Qin Xiaojun
Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China