Review
Research on the relationship between environmental chemical pollutant exposure and epigenetics
Rui Qingyan, Li Xin, Zhang Hongbao, Guo Xuemei, Zheng Na, Zhao Lei, Guo Liqiong, Li Penghui, Yue Junjie
Published 2020-03-20
Cite as Chin Ind Hyg Occup Dis, 2020,38(03): 237-240. DOI: 10.3760/cma.j.cn121094-20190621-00259
Abstract
Environmental chemical pollutants are increasing, which brings various harms to human health. Epigenetics may be an important medium between exposure to environmental chemical contaminants and adverse health effects. Many environmental chemical pollutant exposures can regulate gene expression and promote disease occurrence and development through epigenetic mechanisms. This review outlines the mechanisms of epigenetics and the latest research advances in exposure and epigenetics of several environmental chemical substances (heavy metal arsenic, bisphenol A, dioctyl phthalate and benzene). To further understand and study the relationship between environmental chemical pollutant exposures and epigenetics in order to elucidate the mechanisms of disease occurrence and development.
Key words:
Epigenetic regulation; Environmental chemical; Pollutants; Exposure; DNA methylation; Histone modification; miRNA
Contributor Information
Rui Qingyan
School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China
Li Xin
Department of Labor Hygiene and Environmental Hygiene, School of Public Health, Tianjin Medical University, Tianjin 300070, China
Zhang Hongbao
Tianjin Dongli District Wuxia Street Community Health Service Center, Tianjin 300302, China
Guo Xuemei
Tianjin Medical University Library, Tianjin 300070, China
Zheng Na
School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China
Zhao Lei
School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China
Guo Liqiong
Department of Labor Hygiene and Environmental Hygiene, School of Public Health, Tianjin Medical University, Tianjin 300070, China
Li Penghui
School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China
Yue Junjie
School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China
